Radiation exposure can occur from medical imaging and therapy, natural background radiation from cosmic rays or radon, and intentional exposure through radiation bioterrorism. This Independent Scientist Award will give me the opportunity to focus on research to dissect mechanisms of radiation response and injury by utilizing genetically engineered mice. Ultimately, this information will lay the groundwork for improved cancer therapy, space exploration, and novel countermeasures against radiation. This Independent Scientist (K02) award will support Dr. Kirsch to use mouse genetics to study mechanisms of acute and late effects from radiation therapy. These in vivo studies will provide a mechanistic foundation for the design of safe and effective countermeasures against radiation that do not inadvertently increase late effects of radiation.

Public Health Relevance

This Independent Scientist (K02) award will support Dr. Kirsch to use mouse genetics to study mechanisms of acute and late effects from radiation therapy. These in vivo studies will provide a mechanistic foundation for the design of safe and effective countermeasures against radiation that do not inadvertently increase late effects of radiation.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02AI093866-03
Application #
8417749
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
2011-02-03
Project End
2016-01-31
Budget Start
2013-02-01
Budget End
2014-01-31
Support Year
3
Fiscal Year
2013
Total Cost
$100,197
Indirect Cost
$7,422
Name
Duke University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
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Wong, Philip; Houghton, Peter; Kirsch, David G et al. (2014) Combining targeted agents with modern radiotherapy in soft tissue sarcomas. J Natl Cancer Inst 106:
Sachdeva, Mohit; Mito, Jeffrey K; Lee, Chang-Lung et al. (2014) MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes. J Clin Invest 124:4305-19
Lee, Chang-Lung; Min, Hooney; Befera, Nicholas et al. (2014) Assessing cardiac injury in mice with dual energy-microCT, 4D-microCT, and microSPECT imaging after partial heart irradiation. Int J Radiat Oncol Biol Phys 88:686-93
Schönhuber, Nina; Seidler, Barbara; Schuck, Kathleen et al. (2014) A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer. Nat Med 20:1340-7

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