Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Scientist Development Award - Research (K02)
Project #
1K02AR001985-01
Application #
2077585
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Project Start
1996-07-01
Project End
2001-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Physiology
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
McDearmon, Erin L; Combs, Ariana C; Sekiguchi, Kiyotoshi et al. (2006) Brain alpha-dystroglycan displays unique glycoepitopes and preferential binding to laminin-10/11. FEBS Lett 580:3381-5
Combs, Ariana C; Ervasti, James M (2005) Enhanced laminin binding by alpha-dystroglycan after enzymatic deglycosylation. Biochem J 390:303-9
McDearmon, Erin L; Combs, Ariana C; Ervasti, James M (2003) Core 1 glycans on alpha-dystroglycan mediate laminin-induced acetylcholine receptor clustering but not laminin binding. J Biol Chem 278:44868-73
Rybakova, Inna N; Patel, Jitandrakumar R; Davies, Kay E et al. (2002) Utrophin binds laterally along actin filaments and can couple costameric actin with sarcolemma when overexpressed in dystrophin-deficient muscle. Mol Biol Cell 13:1512-21
Smirnov, Sergei P; McDearmon, Erin L; Li, Shaohua et al. (2002) Contributions of the LG modules and furin processing to laminin-2 functions. J Biol Chem 277:18928-37
Warner, Laura E; DelloRusso, Christiana; Crawford, Robert W et al. (2002) Expression of Dp260 in muscle tethers the actin cytoskeleton to the dystrophin-glycoprotein complex and partially prevents dystrophy. Hum Mol Genet 11:1095-105
McDearmon, E L; Combs, A C; Ervasti, J M (2001) Differential Vicia villosa agglutinin reactivity identifies three distinct dystroglycan complexes in skeletal muscle. J Biol Chem 276:35078-86
Orlova, A; Rybakova, I N; Prochniewicz, E et al. (2001) Binding of dystrophin's tandem calponin homology domain to F-actin is modulated by actin's structure. Biophys J 80:1926-31
Rybakova, I N; Patel, J R; Ervasti, J M (2000) The dystrophin complex forms a mechanically strong link between the sarcolemma and costameric actin. J Cell Biol 150:1209-14
Amann, K J; Guo, A W; Ervasti, J M (1999) Utrophin lacks the rod domain actin binding activity of dystrophin. J Biol Chem 274:35375-80

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