The primary aim of this K02 competing renewal application is to further the applicant?s scientific development in the area of treatment of drug dependent patients, particularly those who are """"""""dually diagnosed"""""""" with drug abuse and coexisting psychiatric illness. Two major hypotheses guide the applicant?s current and planned research. The first is that since drug dependent and dually diagnosed patients are a heterogeneous group, identifying meaningful subgroups of patients and targeting specific therapies to these subgroups will improve treatment outcome. The second major hypothesis is that studying the integration of different treatment approaches (e.g., the combination of pharmacotherapy and psychotherapy) can lead to improved treatment for drug dependent patients. This application is designed to strengthen the applicant?s involvement in five funded projects as PI or Co-Investigator. The following funded projects are currently being pursued by the applicant: 1) a NIDA Behavioral Therapies Development Project to compare two different forms of group therapy for patients with bipolar disorder and substance dependence (DA09400, PI); 2) a multi-site randomized controlled trial evaluating combinations of pharmacotherapy and behavioral therapies in the treatment of alcohol dependence (AA11756, Site PI); 3) a multi-site study examining the genetics of cocaine dependence (DA12849, Site PI); 4) a NIDA-funded project examining the potential efficacy of CDP-choline in the treatment of cocaine dependence (DA11098, Co-Investigator); and 5) a multicenter NIMH-funded project to examine optimal treatments for individuals with bipolar disorder, for which the applicant will examine treatments for those patients with coexisting substance use disorder (MH80001, Substance Abuse Pathway Leader and Co-Investigator). The applicant proposes to expand his research capabilities by learning more about genetics and statistical methods through guided tutorials. Finally, the applicant will mentor younger investigators in their drug abuse research careers and serve the field in general through work as a reviewer on the NIDA Treatment Research IRG and participation in national organizations and editorial boards of addiction journals.
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| Levy, Boaz; Medina, Anna Marie; Manove, Emily et al. (2011) The characteristics of a discrete mood episode, neuro-cognitive impairment and re-hospitalization in bipolar disorder. J Psychiatr Res 45:1048-54 |
| Stulz, Niklaus; Thase, Michael E; Gallop, Robert et al. (2011) Psychosocial treatments for cocaine dependence: the role of depressive symptoms. Drug Alcohol Depend 114:41-8 |
| Stulz, Niklaus; Gallop, Robert; Lutz, Wolfgang et al. (2010) Examining differential effects of psychosocial treatments for cocaine dependence: an application of latent trajectory analyses. Drug Alcohol Depend 106:164-72 |
| Kalayasiri, Rasmon; Gelernter, Joel; Farrer, Lindsay et al. (2010) Adolescent cannabis use increases risk for cocaine-induced paranoia. Drug Alcohol Depend 107:196-201 |
| DiClemente, Carlo C; Doyle, Suzanne R; Donovan, Dennis (2009) Predicting treatment seekers' readiness to change their drinking behavior in the COMBINE Study. Alcohol Clin Exp Res 33:879-92 |
| LoCastro, Joseph S; Youngblood, Marston; Cisler, Ron A et al. (2009) Alcohol treatment effects on secondary nondrinking outcomes and quality of life: the COMBINE study. J Stud Alcohol Drugs 70:186-96 |
| Kranzler, Henry R; Wilcox, Marsha; Weiss, Roger D et al. (2008) The validity of cocaine dependence subtypes. Addict Behav 33:41-53 |
| Meade, Christina S; Graff, Fiona S; Griffin, Margaret L et al. (2008) HIV risk behavior among patients with co-occurring bipolar and substance use disorders: associations with mania and drug abuse. Drug Alcohol Depend 92:296-300 |
| Donovan, Dennis M; Anton, Raymond F; Miller, William R et al. (2008) Combined pharmacotherapies and behavioral interventions for alcohol dependence (The COMBINE Study): examination of posttreatment drinking outcomes. J Stud Alcohol Drugs 69:5-13 |
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