This is a competitive renewal application for a K02 award. During the prior award period, the candidate's research focused on the regulation and function of cortical cholinergic inputs. Results substantiated hypotheses about the mediation of attentional functions by cortical cholinergic inputs, the regulation of this system by basal forebrain afferents, including projections originating in the nucleus accumbens and prefrontal cortex. Furthermore, hypotheses about the contribution of abnormally regulated cortical cholinergic inputs to the cognitive symptoms of major neuropsychiatric disorders were developed and tested. This research utilized a broad range of behavioral neuroscience methods, including operant procedures designed for the assessment of different aspects of attention, and the measurement of acetylcholine (ACh) efflux and neuronal activity in task-performing animals. In addition to continuing research in these areas, three new research avenues are proposed for further development during the next award period. These activities will focus on (1) the validation of a biosensor method for the rapid measurement of choline concentrations as a measure of ACh release with high temporal resolution, and the integration of this method into our main research program, (2) the investigation of interactions between the effects of early-life disruption of trophic factor support of cortical cholinergic inputs, transient ischemic attacks, and aging on the regulation and function of cortical cholinergic inputs, and (3) on the development of a task to be used in a neuropsychological and psychopharmacological research program designed to test hypotheses about the role of the cholinergic system in mediating impairments in the ability to divide attention between competing cognitive demands in humans. The renewal of the KO2 would allow this candidate to devote at least 75% of his time for multidisciplinary research on the neurobiology of attentional functions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research (K02)
Project #
2K02MH001072-06
Application #
6720594
Study Section
Integrative, Functional and Cognitive Neuroscience 8 (IFCN)
Program Officer
Winsky, Lois M
Project Start
2003-12-03
Project End
2004-08-31
Budget Start
2003-12-03
Budget End
2004-08-31
Support Year
6
Fiscal Year
2004
Total Cost
$122,861
Indirect Cost
Name
Ohio State University
Department
Neurosciences
Type
Schools of Medicine
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
Gritton, Howard J; Sutton, Blair C; Martinez, Vicente et al. (2009) Interactions between cognition and circadian rhythms: attentional demands modify circadian entrainment. Behav Neurosci 123:937-48
Sarter, Martin; Parikh, Vinay; Howe, W Matthew (2009) Phasic acetylcholine release and the volume transmission hypothesis: time to move on. Nat Rev Neurosci 10:383-90
Sarter, Martin; Martinez, Vicente; Kozak, Rouba (2009) A neurocognitive animal model dissociating between acute illness and remission periods of schizophrenia. Psychopharmacology (Berl) 202:237-58
Nuechterlein, Keith H; Luck, Steven J; Lustig, Cindy et al. (2009) CNTRICS final task selection: control of attention. Schizophr Bull 35:182-96
Broussard, John I; Karelina, Kate; Sarter, Martin et al. (2009) Cholinergic optimization of cue-evoked parietal activity during challenged attentional performance. Eur J Neurosci 29:1711-22
Demeter, Elise; Sarter, Martin; Lustig, Cindy (2008) Rats and humans paying attention: cross-species task development for translational research. Neuropsychology 22:787-99
Parikh, Vinay; Sarter, Martin (2008) Cholinergic mediation of attention: contributions of phasic and tonic increases in prefrontal cholinergic activity. Ann N Y Acad Sci 1129:225-35
Sarter, Martin (2008) The substantia innominata remains incognita: pressing research themes on basal forebrain neuroanatomy. Brain Struct Funct 213:11-5
Giuliano, Chiara; Parikh, Vinay; Ward, Josh R et al. (2008) Increases in cholinergic neurotransmission measured by using choline-sensitive microelectrodes: enhanced detection by hydrolysis of acetylcholine on recording sites? Neurochem Int 52:1343-50
Zmarowski, Amy; Sarter, Martin; Bruno, John P (2007) Glutamate receptors in nucleus accumbens mediate regionally selective increases in cortical acetylcholine release. Synapse 61:115-23

Showing the most recent 10 out of 60 publications