The proposed application is for a 5 year competing renewal of a K02 award. The current award has allowed the candidate to develop and complete many studies on the relationship between novel prenatal exposures and risk of schizophrenia, using rigorous methodologic approaches in a large birth cohort. These findings included the first serologic evidence that several prenatal infections and immune markers increased the vulnerability to schizophrenia. In the present application, the candidate seeks to extend his ongoing theme of research on the epidemiology of prenatal factors and adult psychopathology in new and important directions.
The research aims i nclude: 1) examining the specificity of prenatal factors that have been associated previously with schizophrenia by investigating their relationship with bipolar disorder;2) investigating whether specific prenatal micronutrients [vitamin B12, iron (ferritin), vitamin A (retinol)] are associated with an increased risk of adult schizophrenia;3) examining the interplay between genetic polymorphisms and prenatal nutrients in the etiology of schizophrenia. The career development plan will provide the candidate with the necessary expertise to address questions that represent the confluence of his existing skill set and the following three training activities necessary to carry out the proposed research objectives. The areas of training include: 1) research in the neurobiology and pathogenesis of bipolar disorder;2) nutrition;3) genetics. These activities will include periodic discussions with experts in their respective fields, formal coursework, seminars, and scientific meetings, and didactic readings. The research plan will also serve as a vehicle by which the candidate will further his ability to practically apply his new knowledge base to the above research objectives. The proposed work has important implications for the investigator's ongoing career development in the identification of new prenatal factors for schizophrenia and bipolar disorder, and the discovery of putative susceptibility genes that interact with these exposures.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Scientist Development Award - Research (K02)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-HOP-E (02))
Program Officer
Rubio, Mercedes
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Columbia University (N.Y.)
Schools of Medicine
New York
United States
Zip Code
Brown, Alan S; Gyllenberg, David; Hinkka-Yli-Salomäki, Susanna et al. (2017) Altered growth trajectory of head circumference during infancy and schizophrenia in a National Birth Cohort. Schizophr Res 182:115-119
Chudal, Roshan; Sourander, Andre; Surcel, Heljä-Marja et al. (2017) Gestational maternal C--reactive protein and risk of bipolar disorder among young individuals in a Nationwide Birth Cohort. J Affect Disord 208:41-46
Fineberg, Anna M; Ellman, Lauren M; Schaefer, Catherine A et al. (2016) Fetal exposure to maternal stress and risk for schizophrenia spectrum disorders among offspring: Differential influences of fetal sex. Psychiatry Res 236:91-7
Freedman, David; Bao, Yuanyuan; Shen, Ling et al. (2016) Maternal T. gondii, offspring bipolar disorder and neurocognition. Psychiatry Res 243:382-9
Niemelä, Solja; Sourander, Andre; Surcel, Heljä-Marja et al. (2016) Prenatal Nicotine Exposure and Risk of Schizophrenia Among Offspring in a National Birth Cohort. Am J Psychiatry 173:799-806
Canetta, S; Bolkan, S; Padilla-Coreano, N et al. (2016) Maternal immune activation leads to selective functional deficits in offspring parvalbumin interneurons. Mol Psychiatry 21:956-68
Timonen-Soivio, Laura; Vanhala, Raija; Malm, Heli et al. (2016) Brief Report: Syndromes in Autistic Children in a Finnish Birth Cohort. J Autism Dev Disord 46:2780-4
Gyllenberg, David; Sourander, Andre; Surcel, Heljä-Marja et al. (2016) Hypothyroxinemia During Gestation and Offspring Schizophrenia in a National Birth Cohort. Biol Psychiatry 79:962-70
Brown, Alan S; Surcel, Heljä-Marja; Hinkka-Yli-Salomäki, Susanna et al. (2015) Maternal thyroid autoantibody and elevated risk of autism in a national birth cohort. Prog Neuropsychopharmacol Biol Psychiatry 57:86-92
Freedman, David; Brown, Alan S; Shen, Ling et al. (2015) Perinatal oxytocin increases the risk of offspring bipolar disorder and childhood cognitive impairment. J Affect Disord 173:65-72

Showing the most recent 10 out of 72 publications