Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Modified Research Career Development Award (K04)
Project #
5K04AR001823-05
Application #
3071395
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1989-09-30
Project End
1994-08-31
Budget Start
1993-09-01
Budget End
1994-08-31
Support Year
5
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Turka, L A; Goodman, R E; Rutkowski, J L et al. (1995) Interleukin 12: a potential link between nerve cells and the immune response in inflammatory disorders. Mol Med 1:690-9
Nickoloff, B J; Kunkel, S L; Burdick, M et al. (1995) Severe combined immunodeficiency mouse and human psoriatic skin chimeras. Validation of a new animal model. Am J Pathol 146:580-8
Nickoloff, B J; Turka, L A; Mitra, R S et al. (1995) Direct and indirect control of T-cell activation by keratinocytes. J Invest Dermatol 105:25S-29S
Mitra, R S; Judge, T A; Nestle, F O et al. (1995) Psoriatic skin-derived dendritic cell function is inhibited by exogenous IL-10. Differential modulation of B7-1 (CD80) and B7-2 (CD86) expression. J Immunol 154:2668-77
Fivenson, D P; Nickoloff, B J (1995) Distinctive dendritic cell subsets expressing factor XIIIa, CD1a, CD1b and CD1c in mycosis fungoides and psoriasis. J Cutan Pathol 22:223-8
Naidu, Y M; Rosen, E M; Zitnick, R et al. (1994) Role of scatter factor in the pathogenesis of AIDS-related Kaposi sarcoma. Proc Natl Acad Sci U S A 91:5281-5
Nickoloff, B J; Nestle, F O; Zheng, X G et al. (1994) T lymphocytes in skin lesions of psoriasis and mycosis fungoides express B7-1: a ligand for CD28. Blood 83:2580-6
Saed, G; Fivenson, D P; Naidu, Y et al. (1994) Mycosis fungoides exhibits a Th1-type cell-mediated cytokine profile whereas Sezary syndrome expresses a Th2-type profile. J Invest Dermatol 103:29-33
Nestle, F O; Turka, L A; Nickoloff, B J (1994) Characterization of dermal dendritic cells in psoriasis. Autostimulation of T lymphocytes and induction of Th1 type cytokines. J Clin Invest 94:202-9
Nickoloff, B J; Naidu, Y (1994) Perturbation of epidermal barrier function correlates with initiation of cytokine cascade in human skin. J Am Acad Dermatol 30:535-46

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