This application is for the renewal of a Senior Scientist Award (SSA) under NIAAA sponsorship. In keeping with the goals of the prior term of the SSA, its renewal would permit the PI to continue to: (a) devote all of her research efforts to alcoholism, (b) participate in structural and functional neuroimaging in the study of alcoholism-related brain abnormalities, and (c) provide mentoring to women scientists. In conjunction with our recently funded R01 AA007112, we will continue to examine the interacting effects of alcoholism and gender on affective (emotional) and conative (intentional) functions. We will assess alcoholism-related vulnerabilities and dysfunction in fronto-limbic brain systems related to emotion, reward, and intention. In combination with psychophysiological monitoring and behavioral testing, we will utilize fMRI to probe responses to affective stimuli. Thus, peripheral electrodermal activity will be recorded concurrently with central hemodynamic (fMRI) changes in order to examine the coupling between autonomic and central measures during emotional activation. Structural MRI analyses will include morphometric assessment of brain structures involved in these fronto-limbic emotion and reward circuits, and diffusion tensor imaging (DTI) will be applied to assess coherence of white matter tracts connecting frontal regions with limbic, ventral striatal, and posterior cerebral systems. These experiments will probe the effects of chronic alcoholism on emotional perception, modulation, and memory. We will focus on brain structure and function underlying these neurobehavioral domains, as well as gender effects in association with alcoholism. Participants will be abstinent alcoholic men and women, ages 18-50, and nonalcoholic men and women group-matched on age, education, and IQ. The fMRI experiments will involve varying both the emotional content of the materials presented (emotional words and pictures), and the type of cognitive ability needed for task performance. Of particular focus in the imaging studies are fronto-limbic regions of interest (ROIs) tied to affective and conative functioning, regions we hypothesize to be associated with neuroanatomical, psychophysiological, and neurobehavioral deficits in alcoholism. Overall, we aim to sharpen distinctions among neurobehavioral sequelae of alcoholism in men and women, and to contribute valuable information about the neurobiology of cognitive aspects of emotion and intention deficits in alcoholism.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Scientist Award (K05)
Project #
5K05AA000219-15
Application #
8118071
Study Section
Special Emphasis Panel (ZAA1-DD (91))
Program Officer
Matochik, John A
Project Start
1996-12-01
Project End
2014-07-31
Budget Start
2011-08-01
Budget End
2014-07-31
Support Year
15
Fiscal Year
2011
Total Cost
$254,328
Indirect Cost
Name
Boston University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Seitz, Johanna; Sawyer, Kayle S; Papadimitriou, George et al. (2017) Alcoholism and sexual dimorphism in the middle longitudinal fascicle: a pilot study. Brain Imaging Behav 11:1006-1017
Blum, Kenneth; Febo, Marcelo; Badgaiyan, Rajendra D et al. (2017) Common Neurogenetic Diagnosis and Meso-Limbic Manipulation of Hypodopaminergic Function in Reward Deficiency Syndrome (RDS): Changing the Recovery Landscape. Curr Neuropharmacol 15:184-194
Schoenthaler, Stephen J; Blum, Kenneth; Fried, Lyle et al. (2017) The effects of residential dual diagnosis treatment on alcohol abuse. J Syst Integr Neurosci 3:
Blum, Kenneth; Simpatico, Thomas; Febo, Marcelo et al. (2017) Hypothesizing Music Intervention Enhances Brain Functional Connectivity Involving Dopaminergic Recruitment: Common Neuro-correlates to Abusable Drugs. Mol Neurobiol 54:3753-3758
Sawyer, Kayle S; Oscar-Berman, Marlene; Barthelemy, Olivier J et al. (2017) Gender dimorphism of brain reward system volumes in alcoholism. Psychiatry Res 263:15-25
Vitali, Mario; Napolitano, Carmen; Berman, Marlene Oscar et al. (2016) Neurophysiological Measures and Alcohol Use Disorder (AUD): Hypothesizing Links between Clinical Severity Index and Molecular Neurobiological Patterns. J Addict Res Ther 5:
McLaughlin, Thomas; Blum, Kenneth; Oscar-Berman, Marlene et al. (2015) Using the Neuroadaptagen KB200z™ to Ameliorate Terrifying, Lucid Nightmares in RDS Patients: the Role of Enhanced, Brain-Reward, Functional Connectivity and Dopaminergic Homeostasis. J Reward Defic Syndr 1:24-35
Blum, Kenneth; Oscar-Berman, Marlene; Braverman, Eric R et al. (2015) Enhancing Brain Pregnenolone May Protect Cannabis Intoxication but Should Not Be Considered as an Anti-addiction Therapeutic: Hypothesizing Dopaminergic Blockade and Promoting Anti-Reward. J Reward Defic Syndr 1:20-23
McLaughlin, Thomas; Blum, Kenneth; Oscar-Berman, Marlene et al. (2015) Putative dopamine agonist (KB220Z) attenuates lucid nightmares in PTSD patients: role of enhanced brain reward functional connectivity and homeostasis redeeming joy. J Behav Addict 4:106-15
Modestino, Edward Justin; Blum, Kenneth; Oscar-Berman, Marlene et al. (2015) Reward Deficiency Syndrome: Attentional/Arousal Subtypes, Limitations of Current Diagnostic Nosology, and Future Research. J Reward Defic Syndr 1:6-9

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