The Senior Scientist Research and Mentorship Award is targeted for """"""""outstanding senior scientists who have demonstrated a sustained level of high productivity conducting biomedical research"""""""" in order to protect their time to continue research while mentoring the """"""""next generation"""""""" of investigators. With more than 25 years of experience in clinical alcohol research (over 20 clinical trials, seminal work in craving (OCDS), biomarkers of drinking (CDT), neuroimaging, and more recently in genetic and pharmacogenomics), over 15 years of continued R01 funding, 16 years of being a Scientific Director of an Alcohol Research Center, with 245 peer reviewed publications, and international recognition, the candidate meets and exceeds the requirements as an outstanding senior scientist. He has been elected to high leadership positions of leading academic/research societies, a previous leader of the COMBINE Study, and is sought out as a mentor for his expertise in bridging the gap between basic and clinical research. He has accomplished this while maintaining an active training program in alcohol research, including 20 years as Director or Co-Director of an NIAAA-sponsored T32 Research Training Grant. He has personally mentored 34 professionals (23 MDs and 11 PhDs), 20 of those in the past 4 years. Many have secured career development and independent alcohol research funding and remain tied to the alcohol field. His understanding of both the mechanisms of, and applications to, the treatment of alcohol disorders is atypical and rare. This award is important to the candidate for two major reasons. First, it will provide him with protected time to keep his alcohol research career on the cutting edge by enabling him to continue formal and informal training in genetics (e.g. epigenetics), proteomics (e.g. glycoproteomics), and new/advanced neuroimaging skills (fMRI connectivity analysis, diffusion kurtosis, and H1-magnetic resonance spectroscopy), apply these essential areas of science to his own alcohol research (as outlined), and communicate new discoveries to the alcohol treatment field in general. Second, this award will provide the candidate with protected time from additional clinical and administrative duties to apply his vast experience and newly acquired skills to his mentoring activities and the development of younger clinical- scientists. With the NIH and the American Association of Medical Colleges highlighting the large, unmet need in the U.S. for clinical and translational researchers (especially in the area of genomics) and with millions of Americans suffering from alcohol disorders, who are underserved and who cost the US economy over $200 billion each year, there is a need to push clinical research forward, a need to ensure our senior scientists are on the cutting edge in their own research, and a need to train future scientists to carry on this research to find effective treatments. This K05 Senior Scientist Career and Mentoring Award will allow this to happen.

Public Health Relevance

Genomics, Proteomics and Neuroimaging technologies have opened new vistas for advancing the understanding of the biology of alcohol effects and alcohol dependence in humans. This K05 award will allow a preeminent alcohol research clinical scientist to gain new skills in these areas and to mentor the next generation of alcohol clinical and translational researchers.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Research Scientist Award (K05)
Project #
Application #
Study Section
Health Services Research Review Subcommittee (AA)
Program Officer
Roach, Deidra
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Medical University of South Carolina
Schools of Medicine
United States
Zip Code
Prisciandaro, J J; Tolliver, B K; Prescot, A P et al. (2017) Unique prefrontal GABA and glutamate disturbances in co-occurring bipolar disorder and alcohol dependence. Transl Psychiatry 7:e1163
Schacht, Joseph P; Randall, Patrick K; Latham, Patricia K et al. (2017) Predictors of Naltrexone Response in a Randomized Trial: Reward-Related Brain Activation, OPRM1 Genotype, and Smoking Status. Neuropsychopharmacology 42:2640-2653
Anton, Raymond F; Schacht, Joseph P; Voronin, Konstantin E et al. (2017) Aripiprazole Suppression of Drinking in a Clinical Laboratory Paradigm: Influence of Impulsivity and Self-Control. Alcohol Clin Exp Res 41:1370-1380
Stewart, Scott H; Reuben, Adrian; Anton, Raymond F (2017) Relationship of Abnormal Chromatographic Pattern for Carbohydrate-Deficient Transferrin with Severe Liver Disease. Alcohol Alcohol 52:24-28
Hahn, Judith A; Anton, Raymond F; Javors, Martin A (2016) The Formation, Elimination, Interpretation, and Future Research Needs of Phosphatidylethanol for Research Studies and Clinical Practice. Alcohol Clin Exp Res 40:2292-2295
McHugh, R Kathryn; Fitzmaurice, Garrett M; Griffin, Margaret L et al. (2016) Association between a brief alcohol craving measure and drinking in the following week. Addiction 111:1004-10
Prisciandaro, James J; Schacht, Joseph P; Prescot, Andrew P et al. (2016) Associations Between Recent Heavy Drinking and Dorsal Anterior Cingulate N-Acetylaspartate and Glutamate Concentrations in Non-Treatment-Seeking Individuals with Alcohol Dependence. Alcohol Clin Exp Res 40:491-6
Boyd, Stephen J; Schacht, Joseph P; Prisciandaro, James J et al. (2016) Alcohol-Induced Stimulation Mediates the Effect of a GABRA2 SNP on Alcohol Self-Administrated among Alcohol-Dependent Individuals. Alcohol Alcohol 51:549-54
Adams, Zachary W; Schacht, Joseph P; Randall, Patrick et al. (2016) The Reasons for Heavy Drinking Questionnaire: Factor Structure and Validity in Alcohol-Dependent Adults Involved in Clinical Trials. J Stud Alcohol Drugs 77:354-61
Cortese, Bernadette M; Uhde, Thomas W; LaRowe, Steven D et al. (2015) Olfactory cue reactivity in nicotine-dependent adult smokers. Psychol Addict Behav 29:91-6

Showing the most recent 10 out of 50 publications