The K05 award will provide Dr. Thomas L Vaughan with protected time (30% FTE) to pursue key research questions related to the etiology and prevention of esophageal adenocarcinoma, a cancer that has increased over six-fold in incidence over three decades. It will also provide for protected time (20% FTE) to expand his already extensive mentoring activities of students and other junior investigators at the University of Washington (UW) and the Fred Hutchinson Cancer Research Center (FHCRC). Dr. Vaughan was one of the founders of the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON), an international consortium of over 30 investigators representing 16 studies, supported in part by NCI and NIDDK, and was elected as the first Chair of the Steering Committee. The research aspects of this award will be conducted in the context of the BEACON, and consist of: i) continued analyses of data and tissue collected as part of a community-based case-control studies of incident Barrett's for which Dr. Vaughan was PI, ii) pooled analyses of data from multiple population-based studies carried out by BEACON investigators, and iii) development of new collaborative research projects within BEACON that take advantage of the diverse populations represented, and existing banks of well-characterized tissues. Dr. Vaughan has a well-established track record of mentoring graduate students and postdoctoral fellows, as well as junior faculty in Epidemiology and related disciplines. He was Co-director of the Environmental Epidemiology Training Grant from 1990-2006;in 2005 he assumed responsibility as Director of the NCI-funded Cancer Epidemiology and Biostatistics Training Grant (T32CA09168). He is a frequent guest lecturer in established epidemiology courses, and has served on 23 masters thesis committees and 20 doctoral dissertation committees. Expanded mentoring activities on the K05 will include: i) those associated with his responsibilities on the training grant, ii) his ongoing mentoring of other trainees from Epidemiology and related departments, and junior faculty across public health disciplines at the UW and FHCRC, and iii) two new pre- or post-doctoral students working directly on K05-associated research activities.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Scientist Award (K05)
Project #
5K05CA124911-03
Application #
7629722
Study Section
Subcommittee G - Education (NCI)
Program Officer
Perkins, Susan N
Project Start
2007-07-23
Project End
2012-06-30
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
3
Fiscal Year
2009
Total Cost
$153,646
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109
Dong, Jing; Levine, David M; Buas, Matthew F et al. (2018) Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett's Esophagus. Clin Gastroenterol Hepatol 16:1598-1606.e4
Dai, James Y; Wang, Xiaoyu; Buas, Matthew F et al. (2018) Whole-genome sequencing of esophageal adenocarcinoma in Chinese patients reveals distinct mutational signatures and genomic alterations. Commun Biol 1:174
Galipeau, Patricia C; Oman, Kenji M; Paulson, Thomas G et al. (2018) NSAID use and somatic exomic mutations in Barrett's esophagus. Genome Med 10:17
Dong, Jing; Buas, Matthew F; Gharahkhani, Puya et al. (2018) Determining Risk of Barrett's Esophagus and Esophageal Adenocarcinoma Based on Epidemiologic Factors and Genetic Variants. Gastroenterology 154:1273-1281.e3
Li, Nan; Petrick, Jessica L; Steck, Susan E et al. (2017) A pooled analysis of dietary sugar/carbohydrate intake and esophageal and gastric cardia adenocarcinoma incidence and survival in the USA. Int J Epidemiol 46:1836-1846
Buas, Matthew F; He, Qianchuan; Johnson, Lisa G et al. (2017) Germline variation in inflammation-related pathways and risk of Barrett's oesophagus and oesophageal adenocarcinoma. Gut 66:1739-1747
Contino, Gianmarco; Vaughan, Thomas L; Whiteman, David et al. (2017) The Evolving Genomic Landscape of Barrett's Esophagus and Esophageal Adenocarcinoma. Gastroenterology 153:657-673.e1
Buas, Matthew F; Gu, Haiwei; Djukovic, Danijel et al. (2017) Candidate serum metabolite biomarkers for differentiating gastroesophageal reflux disease, Barrett's esophagus, and high-grade dysplasia/esophageal adenocarcinoma. Metabolomics 13:
Thrift, Aaron P; Vaughan, Thomas L; Anderson, Lesley A et al. (2017) External Validation of the Michigan Barrett's Esophagus Prediction Tool. Clin Gastroenterol Hepatol 15:1124-1126
Gharahkhani, Puya; Tung, Joyce; Hinds, David et al. (2016) Chronic gastroesophageal reflux disease shares genetic background with esophageal adenocarcinoma and Barrett's esophagus. Hum Mol Genet 25:828-35

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