Dr. Ross is internationally recognized for her work in pediatric cancer epidemiology. She has successfully developed several ancillary cross-disciplinary studies to augment epidemiological studies of childhood cancer. Further, as a natural progression of her research in childhood leukemia, she initiated two population-based molecular epidemiology studies of adult hematopoietic malignancies, anticipating that knowledge gained may be informative for all age groups. A K05 award will provide Dr. Ross protected research time (20% FTE) to pursue an innovative transdisciplinary approach toward understanding the etiology of childhood cancers. She plans to involve collaborators from other disciplines to address key questions. The overall outline of proposed research: 1) Application of murine models to augment etiological studies of childhood cancer;2) Exploration of new initiatives utilizing biospecimens for potential future integration into childhood cancer studies;and 3) Expansion of analyses within existing research studies, including infant leukemia and other childhood malignancies, the Children's Oncology Group Childhood Cancer Research Network, and a new statewide study of myelodysplastic syndrome. Dr. Ross'proposed mentoring activities include enriching and expanding (20% FTE) her already wide-ranging mentoring of students (undergraduate, graduate, and post-doctoral) and junior faculty. She is program director of an NIH-funded training grant (T32) dedicated to training the next generation of pediatric cancer epidemiologists. In addition to serving on several master's and dissertation committees, Dr. Ross has served as primary research mentor to 15 graduate students, 8 postdocs, and 7 junior faculty. Her proposed mentoring pool during the K05 award period will include: 1) T32 trainees;2) junior faculty developing careers in pediatric cancer research;and 3) at least three additional junior colleagues involved in K05-supported research activities. A K05 award will support both more concentrated and in-depth mentoring of future pediatric cancer researchers, as well as focus and stimulate new transdisciplinary research initiatives.

Public Health Relevance

Dr. Ross is internationally known for her research that seeks to understand why some children get cancer. She also mentors several junior colleagues and trainees in pediatric cancer epidemiology. To find new breakthroughs, she proposes to intensify her efforts to explore childhood cancer using new data from animal models, newborn dried blood spots, as well as from her own existing studies. She will continue her mentoring activities, with special attention to teaching a transdisciplinary approach.

National Institute of Health (NIH)
Research Scientist Award (K05)
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Study Section
Subcommittee B - Comprehensiveness (NCI)
Program Officer
Perkins, Susan N
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University of Minnesota Twin Cities
Schools of Medicine
United States
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Blair, Cindy K; Kelly, Aaron S; Steinberger, Julia et al. (2014) Feasibility and preliminary efficacy of the effects of flavanoid-rich purple grape juice on the vascular health of childhood cancer survivors: a randomized, controlled crossover trial. Pediatr Blood Cancer 61:2290-6
Jones, Rena R; Yu, Chu-Ling; Nuckols, John R et al. (2014) Farm residence and lymphohematopoietic cancers in the Iowa Women's Health Study. Environ Res 133:353-61
Gleason, Michelle K; Ross, Julie A; Warlick, Erica D et al. (2014) CD16xCD33 bispecific killer cell engager (BiKE) activates NK cells against primary MDS and MDSC CD33+ targets. Blood 123:3016-26
Venkatramani, Rajkumar; Spector, Logan G; Georgieff, Michael et al. (2014) Congenital abnormalities and hepatoblastoma: a report from the Children's Oncology Group (COG) and the Utah Population Database (UPDB). Am J Med Genet A 164A:2250-5
Linabery, Amy M; Prizment, Anna E; Anderson, Kristin E et al. (2014) Allergic diseases and risk of hematopoietic malignancies in a cohort of postmenopausal women: a report from the Iowa Women's Health Study. Cancer Epidemiol Biomarkers Prev 23:1903-12
Valentine, M C; Linabery, A M; Chasnoff, S et al. (2014) Excess congenital non-synonymous variation in leukemia-associated genes in MLL- infant leukemia: a Children's Oncology Group report. Leukemia 28:1235-41
Linabery, Amy M; Erhardt, Erik B; Fonstad, Rachel K et al. (2014) Infectious, autoimmune and allergic diseases and risk of Hodgkin lymphoma in children and adolescents: a Children's Oncology Group study. Int J Cancer 135:1454-69
Hsu, Jennifer; Fink, Deanna; Langer, Erica et al. (2014) PCR-based allelic discrimination for glucose-6-phosphate dehydrogenase (G6PD) deficiency in Ugandan umbilical cord blood. Pediatr Hematol Oncol 31:68-75
Slater, Megan E; Ross, Julie A; Kelly, Aaron S et al. (2014) Physical activity and cardiovascular risk factors in childhood cancer survivors. Pediatr Blood Cancer :
Musselman, Jessica R B; Spector, Logan G; Krailo, Mark D et al. (2014) The Children's Oncology Group Childhood Cancer Research Network (CCRN): case catchment in the United States. Cancer 120:3007-15

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