This Research Scientist Award (K05) will a) generate research on interventions for smokers who are and are not currently interested in quitting and b) assist professional (e.g. SRNT) and governmental (e.g. WHO) organizations interested in tobacco control. The applicant's past research contributions include description of the nicotine withdrawal syndrome, psychiatric comorbidity, the role of expectancies in nicotine effects and caffeine reinforcement and dependence in humans. In the last K02, the applicant averaged 17.2 papers/yr of which he was first author on 12.2/yr and of which 6.2/yr were empirical studies. He founded the Human Behavioral Pharmacology Laboratory (HBPL) at UVM and cofounded the Society for Research on Nicotine and Tobacco (SRNT). This K05 will examine interventions for smokers not interested in quitting: i.e., reduced smoking, using Eclipse, and offering free samples of NRT to use during smoking restrictions or during """"""""test quits."""""""" The K05 will also investigate interventions for smokers currently interested in quitting. i.e, it will compare gradual vs abrupt, group vs individual and patient-vs expert-chosen interventions and interventions for treatment-resistant smokers. The K05 will include assisting other drug abuse researchers at UVM. The applicant will continue to mentor 4-6 students/yr and to explore new disciplines (e.g., diagnostic nosology) and methodologies (e.g. Markov models, IVR technologies). This would be the first NIDA K05 to focus on nicotine dependence.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Scientist Award (K05)
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Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Grossman, Debra
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University of Vermont & St Agric College
Schools of Medicine
United States
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Carpenter, Matthew J; Hughes, John R; Gray, Kevin M et al. (2011) Nicotine therapy sampling to induce quit attempts among smokers unmotivated to quit: a randomized clinical trial. Arch Intern Med 171:1901-7
Hughes, John R (2011) The hardening hypothesis: is the ability to quit decreasing due to increasing nicotine dependence? A review and commentary. Drug Alcohol Depend 117:111-7
Callas, Peter W; Solomon, Laura J; Hughes, John R et al. (2010) The influence of response mode on study results: offering cigarette smokers a choice of postal or online completion of a survey. J Med Internet Res 12:e46
Hughes, John R (2010) A quantitative estimate of the clinical significance of treating tobacco dependence. Am J Prev Med 39:285-6
Hughes, John R; Solomon, Laura J; Livingston, Amy E et al. (2010) A randomized, controlled trial of NRT-aided gradual vs. abrupt cessation in smokers actively trying to quit. Drug Alcohol Depend 111:105-13
Hughes, John R; Suiter, Catherine; Marcy, Theodore (2010) Use and outcomes of a state-funded in-person counselling program. Tob Control 19:260
Hughes, John R (2009) How confident should we be that smoking cessation treatments work? Addiction 104:1637-40
Solomon, Laura J; Hughes, John R; Livingston, Amy et al. (2009) Cognitive barriers to calling a smoking quitline. Nicotine Tob Res 11:1339-46
Hughes, John R (2009) Smokers' beliefs about the inability to stop smoking. Addict Behav 34:1005-9
Hughes, John R; Cohen, Bevin; Callas, Peter W (2009) Treatment seeking for smoking cessation among young adults. J Subst Abuse Treat 37:211-3

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