Specific aims of this study are (i) To determine whether liver DC convert from inert inducers of tolerance to potent immune-stimulators and mediators of inflammation in liver fibrosis, (ii) To determine the contributory role of DC in the pathogenesis of fibrosis and their direct role in HSC activation, (iii) To determine whether blockade of the immunogenic function of liver DC can mitigate the fibrogenic response to liver injury. In vitro and in vivo experiments in Aims 2 and 3 were affected by our loss of cell cultures, mice, and our lab shutdown and then relocation. An extension will help us complete the Aims of the grant which has been very fruitful till this point.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Clinical Investigator Award (CIA) (K08)
Project #
3K08DK085278-05S1
Application #
8673488
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Podskalny, Judith M,
Project Start
2014-01-21
Project End
2016-01-20
Budget Start
2014-01-21
Budget End
2016-01-20
Support Year
5
Fiscal Year
2014
Total Cost
$148,595
Indirect Cost
$11,007
Name
New York University
Department
Surgery
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
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