The long term objective of this application is to develop new treatments for retinopathy of prematurity (ROP), the leading cause of childhood blindness.
Specific Aim I is to develop a new class of novel light-activated anti-angiogenesis drugs for targeted treatment of peripheral neovascularization that occurs in ROP.
Specific Aim II is to use fat derived cells to protect the immature blood vessels in newborns from damage from ROP.
Specific Aim III is to determine whether two molecules involved in blood vessel growth, ephrin-B2 and EphB4, are involved in ROP and if they might be a good target to treat the disease.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08EY019533-05
Application #
8523885
Study Section
Special Emphasis Panel (ZEY1-VSN (03))
Program Officer
Agarwal, Neeraj
Project Start
2009-08-01
Project End
2014-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
5
Fiscal Year
2013
Total Cost
$191,715
Indirect Cost
$14,201
Name
University of Virginia
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
065391526
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Durham, Jennifer T; Dulmovits, Brian M; Cronk, Stephen M et al. (2015) Pericyte chemomechanics and the angiogenic switch: insights into the pathogenesis of proliferative diabetic retinopathy? Invest Ophthalmol Vis Sci 56:3441-59
Durham, Jennifer T; Surks, Howard K; Dulmovits, Brian M et al. (2014) Pericyte contractility controls endothelial cell cycle progression and sprouting: insights into angiogenic switch mechanics. Am J Physiol Cell Physiol 307:C878-92
Mendel, Thomas A; Clabough, Erin B D; Kao, David S et al. (2013) Pericytes derived from adipose-derived stem cells protect against retinal vasculopathy. PLoS One 8:e65691
Tran, Kenneth; Mendel, Thomas A; Holbrook, Kristina L et al. (2012) Construction of an inexpensive, hand-held fundus camera through modification of a consumer "point-and-shoot" camera. Invest Ophthalmol Vis Sci 53:7600-7
Taylor, Alyssa C; Mendel, Thomas A; Mason, Katelyn E et al. (2012) Attenuation of ephrinB2 reverse signaling decreases vascularized area and preretinal vascular tuft formation in the murine model of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci 53:5462-70
Demidova-Rice, Tatiana N; Wolf, Lindsey; Deckenback, Jeffry et al. (2012) Human platelet-rich plasma- and extracellular matrix-derived peptides promote impaired cutaneous wound healing in vivo. PLoS One 7:e32146
Boscolo, Elisa; Stewart, Camille L; Greenberger, Shoshana et al. (2011) JAGGED1 signaling regulates hemangioma stem cell-to-pericyte/vascular smooth muscle cell differentiation. Arterioscler Thromb Vasc Biol 31:2181-92
Schultz, Gregory S; Davidson, Jeffrey M; Kirsner, Robert S et al. (2011) Dynamic reciprocity in the wound microenvironment. Wound Repair Regen 19:134-48
Durham, Jennifer T; Herman, Ira M (2011) Microvascular modifications in diabetic retinopathy. Curr Diab Rep 11:253-64
Demidova-Rice, Tatiana N; Geevarghese, Anita; Herman, Ira M (2011) Bioactive peptides derived from vascular endothelial cell extracellular matrices promote microvascular morphogenesis and wound healing in vitro. Wound Repair Regen 19:59-70

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