Abstract

In this application Dr. Upperman proposes to study the regulation of enterocyte apoptosis induced by NO. Studies into (1) the characterization of enterocyte death after shock and trauma are of clear basic and applied relevance. The expectations are that the studies will provide novel information regarding the mechanism of the regulation of enterocyte death, with particular relevance to signaling pathways, Src-dependent kinases, and bacterial translocation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08GM000696-04
Application #
6780368
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Program Officer
Somers, Scott D
Project Start
2001-08-01
Project End
2006-07-31
Budget Start
2004-08-01
Budget End
2006-07-31
Support Year
4
Fiscal Year
2004
Total Cost
$129,284
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Surgery
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Guner, Yigit S; Friedlich, Philippe; Wee, Choo Phei et al. (2009) State-based analysis of necrotizing enterocolitis outcomes. J Surg Res 157:21-9
Guner, Yigit S; Ochoa, Christian J; Wang, Jin et al. (2009) Peroxynitrite-induced p38 MAPK pro-apoptotic signaling in enterocytes. Biochem Biophys Res Commun 384:221-5
Upperman, Jeffrey S; Camerini, Victoria; Lugo, Brian et al. (2007) Mathematical modeling in necrotizing enterocolitis--a new look at an ongoing problem. J Pediatr Surg 42:445-53
Hackam, David J; Upperman, Jeffrey S; Grishin, Anatoly et al. (2005) Disordered enterocyte signaling and intestinal barrier dysfunction in the pathogenesis of necrotizing enterocolitis. Semin Pediatr Surg 14:49-57
Upperman, Jeffrey S; Pillage, Gina; Siddiqi, Muhammad Q et al. (2005) Dominance of high-producing interleukin 6 and low-producing interleukin 10 and interferon gamma alleles in glucose-6-phosphate dehydrogenase-deficient trauma patients. Shock 23:197-201
Upperman, Jeffrey S; Potoka, Douglas A; Zhang, Xiao-Ru et al. (2003) Mechanism of intestinal-derived fungal sepsis by gliotoxin, a fungal metabolite. J Pediatr Surg 38:966-70