Motor vehicle crashes continue to be the leading cause of mortality and acquired disability in children. Traumatic brain and spinal cord injuries are typically considered the most disabling of these injuries. However, little is known about the specific patterns of injuries that lead to various degrees of functional disability in children and the biomechanical mechanisms for these crash-related disabling injuries. The broad long-term objective of this line of research is to advance the understanding of the nature and causes of functional disability after pediatric injury in sufficient detail to inorm secondary prevention (improved engineering and injury countermeasures) strategies as well as tertiary prevention (improved acute and rehabilitative care) strategies. As a first step in achieving this goal, the current proposal will focus on motor vehicle crashes as a prototypic mechanism of disabling injury in children.
The aims of the project are: 1) To identify the injuries for children 7-18 years old that are associated with moderate to severe functional disability upon discharge from rehabilitation centers, 2) To identify the crash characteristics, direction of impac, occupant contact points, and adequacy of restraint system performance that contribute to the moderately to severely disabling pattern of injuries, and to 3) To create a 3-dimensional dynamic computational model in order to quantify the crash biomechanics, simulate the occupant kinematics, and identify a countermeasure that could mitigate the biomechanical mechanism of injury.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08HD073241-02
Application #
8518434
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Quatrano, Louis A
Project Start
2012-08-01
Project End
2017-05-31
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
2
Fiscal Year
2013
Total Cost
$125,555
Indirect Cost
$9,300
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Corwin, Daniel J; Zonfrillo, Mark R; Master, Christina L et al. (2014) Characteristics of prolonged concussion recovery in a pediatric subspecialty referral population. J Pediatr 165:1207-15
Zonfrillo, Mark R; Locey, Caitlin M; Scarfone, Steven R et al. (2014) Motor vehicle crash-related injury causation scenarios for spinal injuries in restrained children and adolescents. Traffic Inj Prev 15 Suppl 1:S49-55
Zonfrillo, Mark R; Sauber-Schatz, Erin K; Hoffman, Benjamin D et al. (2014) Pediatricians' self-reported knowledge, attitudes, and practices about child passenger safety. J Pediatr 165:1040-5.e1-2
Zonfrillo, Mark R; Durbin, Dennis R; Winston, Flaura K et al. (2014) Residual cognitive disability after completion of inpatient rehabilitation among injured children. J Pediatr 164:130-5
Zonfrillo, Mark R; Durbin, Dennis R; Koepsell, Thomas D et al. (2014) Prevalence of and risk factors for poor functioning after isolated mild traumatic brain injury in children. J Neurotrauma 31:722-7