Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Physician Scientist Award (K11)
Project #
5K11AI000610-02
Application #
3084996
Study Section
(SRC)
Project Start
1984-07-01
Project End
1989-06-30
Budget Start
1985-07-01
Budget End
1986-06-30
Support Year
2
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Harvard University
Department
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
Virgin 4th, H W; Mann, M A; Fields, B N et al. (1991) Monoclonal antibodies to reovirus reveal structure/function relationships between capsid proteins and genetics of susceptibility to antibody action. J Virol 65:6772-81
Virgin 4th, H W; Tyler, K L (1991) Role of immune cells in protection against and control of reovirus infection in neonatal mice. J Virol 65:5157-64
Tyler, K L; Virgin 4th, H W; Bassel-Duby, R et al. (1989) Antibody inhibits defined stages in the pathogenesis of reovirus serotype 3 infection of the central nervous system. J Exp Med 170:887-900
Virgin 4th, H W; Bassel-Duby, R; Fields, B N et al. (1988) Antibody protects against lethal infection with the neurally spreading reovirus type 3 (Dearing). J Virol 62:4594-604
Gonzalez-Scarano, F; Tyler, K L (1987) Molecular pathogenesis of neurotropic viral infections. Ann Neurol 22:565-74
Tyler, K L; Gross, R A; Cascino, G D (1986) Unusual viral causes of transverse myelitis: hepatitis A virus and cytomegalovirus. Neurology 36:855-8
Tyler, K L; McPhee, D A; Fields, B N (1986) Distinct pathways of viral spread in the host determined by reovirus S1 gene segment. Science 233:770-4
Kaye, K M; Spriggs, D R; Bassel-Duby, R et al. (1986) Genetic basis for altered pathogenesis of an immune-selected antigenic variant of reovirus type 3 (Dearing). J Virol 59:90-7
Bassel-Duby, R; Spriggs, D R; Tyler, K L et al. (1986) Identification of attenuating mutations on the reovirus type 3 S1 double-stranded RNA segment with a rapid sequencing technique. J Virol 60:64-7