Yale University School of Medicine and the Yale Pediatric Endocrinology Section are seeking to be one of the centers of excellence in diabetes career development that will allow young pediatric endocrinologists to establish academic careers as independent investigators in diabetes research. In this K12 application, we are requesting ~2 Physician Scientist stipends per year for 5 years. Yale has an impressive array of resources that will support this program, including the research services and research facilities provided by the CTSA-supported Yale Center for Clinical Investigation (YCCI), DERC, Magnetic Resonance Research Center, the PET Center, the Keck Biotechnology Laboratory, Mouse Metabolic Phenotyping Center and a host of other research cores. The Program Director, Assistant Program Director and faculty mentors are highly respected and productive investigators with extensive peer-reviewed grant support to fund trainees'projects and they play key administrative roles in the management of many of the most relevant research resources and facilities. Our faculty members have a long history of extensive collaborations and an outstanding track record in the career development of young physician scientists. The faculty includes three of our former K12 scholars who have developed into outstanding young investigators. Our physician scientist scholars can choose between four major areas of research training (T1D Therapeutics, Obesity/T2 DM, Immunobiology of T1D and Hypoglycemia/ Neurobiology) and 5-8 potential mentors within each area. The K12 Advisory Committee will be comprised of each of the leaders of theses research areas, along with several other senior faculty members in Pediatrics. A centerpiece of our educational program is the Yale Investigative Medicine Program (IMP). IMP offers courses that are part of the Masters Degree in Health Science Research Program curriculum in which all of our scholars who do not have an advanced degree will enroll. Our first two projected K12 scholars are on track to receive IMP PhD's in clinical investigation in 2011.

Public Health Relevance

The Yale K12 Career Development Program is designed to address the marked shortage of young pediatric endocrinologists who are trained and have the skills to develop into outstanding independent investigators in pediatric diabetes research. Yale University School of Medicine (and its Section of Pediatric Endocrinology) is an optimal site for this program, since it has the research resources;the program leadership;the educational curricula;a strong commitment to program goals;an outstanding group of internationally acclaimed senior scientists with established tract records for developing young investigators and access to superior scholar candidates

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12DK094714-03
Application #
8490375
Study Section
Special Emphasis Panel (ZDK1-GRB-C (O2))
Program Officer
Hyde, James F
Project Start
2011-09-16
Project End
2015-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
3
Fiscal Year
2013
Total Cost
$567,336
Indirect Cost
$41,247
Name
Yale University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Van Name, Michelle A; Hilliard, Marisa E; Boyle, Claire T et al. (2017) Nighttime is the worst time: Parental fear of hypoglycemia in young children with type 1 diabetes. Pediatr Diabetes :
Erie, Christine; Van Name, Michelle A; Weyman, Kate et al. (2017) Schooling diabetes: Use of continuous glucose monitoring and remote monitors in the home and school settings. Pediatr Diabetes :
Tamborlane, William V; Pfeiffer, Kathryn M; Brod, Meryl et al. (2017) Understanding bolus insulin dose timing: the characteristics and experiences of people with diabetes who take bolus insulin. Curr Med Res Opin 33:639-645
Cengiz, Eda; Bode, Bruce; Van Name, Michelle et al. (2016) Moving toward the ideal insulin for insulin pumps. Expert Rev Med Devices 13:57-69
Jastreboff, Ania M; Sinha, Rajita; Arora, Jagriti et al. (2016) Altered Brain Response to Drinking Glucose and Fructose in Obese Adolescents. Diabetes 65:1929-39
Van Name, Michelle A; Camp, Anne W; Magenheimer, Elizabeth A et al. (2016) Effective Translation of an Intensive Lifestyle Intervention for Hispanic Women With Prediabetes in a Community Health Center Setting. Diabetes Care 39:525-31
Patel, Neha S; Van Name, Michelle A; Cengiz, Eda et al. (2016) Mitigating Reductions in Glucose During Exercise on Closed-Loop Insulin Delivery: The Ex-Snacks Study. Diabetes Technol Ther 18:794-799
Sherr, Jennifer L; Patel, Neha S; Michaud, Camille I et al. (2016) Mitigating Meal-Related Glycemic Excursions in an Insulin-Sparing Manner During Closed-Loop Insulin Delivery: The Beneficial Effects of Adjunctive Pramlintide and Liraglutide. Diabetes Care 39:1127-34
Van Name, Michelle; Giannini, Cosimo; Santoro, Nicola et al. (2015) Blunted suppression of acyl-ghrelin in response to fructose ingestion in obese adolescents: the role of insulin resistance. Obesity (Silver Spring) 23:653-61
Santoro, Nicola; Caprio, Sonia; Pierpont, Bridget et al. (2015) Hepatic De Novo Lipogenesis in Obese Youth Is Modulated by a Common Variant in the GCKR Gene. J Clin Endocrinol Metab 100:E1125-32

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