This is a competitive renewal application for continued support of a postdoctoral research career development program for obstetrician-gynecologists in fundamental research in reproductive medicine and biology. It is sponsored jointly by the NIH/NICHD, six professional organizations, three pharmaceutical corporations, and three research foundations. The objective of this program is to educate obstetrician-gynecologists in contemporary basic science research to prepare them for research careers in academic medicine. The goal is to help ensure that academic obstetrics and gynecology fulfills its mission to increase research and discovery in the reproductive sciences. Outstanding PhD and MD scientists with broad research experience serve as faculty. A unique feature of this program is that outstanding individuals, upon completion of residency, and in many cases two or three years of clinical subspecialty fellowship, spend two to three years in fundamental research laboratories under the supervision and mentorship of experienced, well-screened, and accomplished scientists (Phase I). Following this experience, scholars spend an additional three-year period establishing their research programs in a Department of Obstetrics and Gynecology (Phase II). During Phase I, scholars are dedicated to full-time research. Following this basic research, the scholar spends three years as a junior faculty member in a Department of Obstetrics and Gynecology with at least 75% time free to develop an independent research career. Phase II is funded from a number of possible sources, including NIH and private grants, and from contributions to the RSDP program from the profession, from philanthropic foundations, industry, and personal sources. Upon completion of this program, the candidate is expected to continue to pursue a career as a productive investigator. This program serves as a model to educate increased numbers of reproductive scientists to develop into leaders in academic Departments of Obstetrics and Gynecology. The RSDP's plan for career development serves as a model for postgraduate medical education, and assures that some of the most promising young physician-investigators in the country will remain in academic investigative obstetrics and gynecology. A great majority of the scholars who have finished Phase II of the Program have dedicated themselves to research in the reproductive sciences and have developed major independent funding support. To date their productivity has been outstanding, and is a credit to the Program.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Physician Scientist Award (Program) (PSA) (K12)
Project #
Application #
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
De Paolo, Louis V
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Francisco
Obstetrics & Gynecology
Schools of Medicine
San Francisco
United States
Zip Code
Sandgren, Jeremy A; Santillan, Mark K; Grobe, Justin L (2016) Breaking a Mother's Heart: Circulating Antiangiogenic Factors and Hypertension During Pregnancy Correlate With Specific Cardiac Dysfunctions. Hypertension 67:1119-20
Mainigi, Monica; Rosenzweig, Jason M; Lei, Jun et al. (2016) Peri-Implantation Hormonal Milieu: Elucidating Mechanisms of Adverse Neurodevelopmental Outcomes. Reprod Sci 23:785-94
Kempuraj, Duraisamy; Thangavel, Ramasamy; Fattal, Ranan et al. (2016) Mast Cells Release Chemokine CCL2 in Response to Parkinsonian Toxin 1-Methyl-4-Phenyl-Pyridinium (MPP(+)). Neurochem Res 41:1042-9
Edlow, Andrea G; Guedj, Faycal; Pennings, Jeroen L A et al. (2016) Males are from Mars, and females are from Venus: sex-specific fetal brain gene expression signatures in a mouse model of maternal diet-induced obesity. Am J Obstet Gynecol 214:623.e1-623.e10
Wallenstein, Matthew B; Jelliffe-Pawlowski, Laura L; Yang, Wei et al. (2016) Inflammatory biomarkers and spontaneous preterm birth among obese women. J Matern Fetal Neonatal Med 29:3317-22
Wesselink, Amelia K; Wise, Lauren A; Rothman, Kenneth J et al. (2016) Caffeine and caffeinated beverage consumption and fecundability in a preconception cohort. Reprod Toxicol 62:39-45
Devor, Eric J; Schickling, Brandon M; Reyes, Henry D et al. (2016) Cullin-5, a ubiquitin ligase scaffold protein, is significantly underexpressed in endometrial adenocarcinomas and is a target of miR-182. Oncol Rep 35:2461-5
Ulrich, Victoria; Gelber, Shari E; Vukelic, Milena et al. (2016) ApoE Receptor 2 Mediation of Trophoblast Dysfunction and Pregnancy Complications Induced by Antiphospholipid Antibodies in Mice. Arthritis Rheumatol 68:730-9
Gonzalez-Rodriguez, Pablo; Cantu, Jessica; O'Neil, Derek et al. (2016) Alterations in expression of imprinted genes from the H19/IGF2 loci in a multigenerational model of intrauterine growth restriction (IUGR). Am J Obstet Gynecol 214:625.e1-625.e11
Wesselink, Amelia K; Wise, Lauren A; Hatch, Elizabeth E et al. (2016) Menstrual cycle characteristics and fecundability in a North American preconception cohort. Ann Epidemiol 26:482-487.e1

Showing the most recent 10 out of 234 publications