This is a competitive renewal application for continued support under new leadership, for the Reproductive Scientist Development Program (RSDP), a multi-disciplinary, multi-institutional research career development program for obstetrician-gynecologists in cell and molecular biology and related fundamental sciences. The objective of this program is to educate obstetrician-gynecologists in contemporary basic science research related to reproductive medicine and biology in order to prepare them for research careers in academic medicine. The overall goal is to help ensure that academic obstetrics and gynecology fulfills its mission to increase research and discovery in the reproductive sciences. Outstanding MD/PhD, PhD, and MD scientists with broad research experience serve as faculty mentors. A unique feature of this program is that outstanding individuals, upon completing a residency in obstetrics and gynecology, and in many cases two or three years of clinical subspecialty fellowship, spend two to three years (Phase I) in fundamental science research laboratories under the supervision and mentorship of experienced, highly regarded accomplished scientists. During Phase I, Scholars are dedicated to full-time research with no clinical obligations. Following this experience, Scholars spend an additional three-year period establishing their research program in a Department of Obstetrics and Gynecology (Phase II). Here, the Scholar serves as a junior faculty member with at least 75% time devoted to developing an independent research career. Historically, Phase I has been entirely funded by NICHD and Phase II has been funded from a number of possible sources, including NIH an private grants, and from contributions to the RSDP program from the obstetrics and gynecologic societies, from philanthropic foundation, industry, departmental, and other sources. This funding mechanism will continue, however, NIH funding will support up to 3 Scholars for the duration of Phase I and Phase II. Upon completion of this program, the Scholar is expected to continue to pursue a career as a productive physician-scientist investigator. This program serves as a model to education increased numbers of reproductive scientists to develop into leaders in academic Departments of Obstetrics and Gynecology, and this is now occurring.

Public Health Relevance

The Reproductive Scientist Development Program plan for career development serves as a model for postgraduate medical education, and assures that some of the most promising young physician-investigators in the country will remain in academic investigative obstetrics and gynecology. A great majority of the Scholars who have finished Phase II of the Program have dedicated themselves to research in the reproductive sciences and have developed major independent funding support. To date their productivity has been outstanding, has contributed greatly to the reproductive sciences, and is a credit for the Program.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Physician Scientist Award (Program) (PSA) (K12)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-DRG-H (SM))
Program Officer
Lamar, Charisee A
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Washington University
Obstetrics & Gynecology
Schools of Medicine
Saint Louis
United States
Zip Code
Lengyel, Ernst; Litchfield, Lacey M; Mitra, Anirban K et al. (2015) Metformin inhibits ovarian cancer growth and increases sensitivity to paclitaxel in mouse models. Am J Obstet Gynecol 212:479.e1-479.e10
Hu, Xiaowen; Feng, Yi; Zhang, Dongmei et al. (2014) A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer. Cancer Cell 26:344-57
Santillan, Mark K; Leslie, Kimberly K; Hamilton, Wendy S et al. (2014) "Collection of a lifetime: a practical approach to developing a longitudinal collection of women's healthcare biological samples". Eur J Obstet Gynecol Reprod Biol 179:94-9
Brouwer-Visser, Jurriaan; Lee, Jiyeon; McCullagh, KellyAnne et al. (2014) Insulin-like growth factor 2 silencing restores taxol sensitivity in drug resistant ovarian cancer. PLoS One 9:e100165
Feltovich, Helen; House, Michael (2014) Innovative methods of cervical assessment and potential for novel treatment. Clin Obstet Gynecol 57:531-6
Mainigi, Monica A; Olalere, Devvora; Burd, Irina et al. (2014) Peri-implantation hormonal milieu: elucidating mechanisms of abnormal placentation and fetal growth. Biol Reprod 90:26
Critchfield, Agatha S; Mccabe, Reid; Klebanov, Nikolai et al. (2014) Biocompatibility of a sonicated silk gel for cervical injection during pregnancy: in vivo and in vitro study. Reprod Sci 21:1266-73
Santillan, Mark K; Santillan, Donna A; Scroggins, Sabrina M et al. (2014) Vasopressin in preeclampsia: a novel very early human pregnancy biomarker and clinically relevant mouse model. Hypertension 64:852-9
Wambach, Carrie M; Patel, Sonal N; Kahn, Daniel A (2014) Maternal and fetal factors that contribute to the localization of T regulatory cells during pregnancy. Am J Reprod Immunol 71:391-400
House, Michael; Tadesse-Telila, Serkalem; Norwitz, Errol R et al. (2014) Inhibitory effect of progesterone on cervical tissue formation in a three-dimensional culture system with human cervical fibroblasts. Biol Reprod 90:18

Showing the most recent 10 out of 168 publications