The purpose of the Child Health Research Career Development Award (CHRCDA) program at the Children's National Health System/Children's Research Institute is to facilitate the development of successful basic science and translational research careers for junior faculty members in pediatrics. The rationale for this program is based on the observation that while many opportunities currently exist to use molecular biology to advance treatment of pediatric diseases, the complex and comprehensive scientific knowledge and practical laboratory experience that are required to capitalize on these opportunities are often deficient among young investigators. Specifically, extended bench experience is typically lacking in the traditional career development of academic pediatricians who have recently completed their clinical training. The CHRCDA addresses this need by providing sufficient protected time for pediatrician-investigators during their initial academic appointment to: 1) take coursework in basic science areas relevant to their research; 2) learn state-of-the art laboratory methodology; 3) develop preliminary data under the supervision of established investigators/mentors that will lead to submission of independent NIH grant applications; and 4) learn to effectively translate accomplishments in pediatric basic and translational research into improvements in child health. In order to accomplish these goals, the CHRCDA Scholars will spend at least 75% effort honing these skills under the mentorship of established investigators/mentors over a 2-4 year period (depending on past experience and area of investigation). During this period, each of the above tasks will be addressed in a systematic fashion, including participation in a core curriculum in research methodology and biostatistics and performance of increasingly independent research in the laboratory of investigators/mentors. We propose for consideration 20 mentors in 4 affinity areas: neuroscience, genetics, immunology, and cell biology. The administrative structure of the CHRCDA includes two Principal Investigators/Program Directors, a Training Director, a Recruiting Officer, a Program Administrator and an Advisory Committee. We propose to select and train a total of 8 CHRCDA scholars at the Assistant Professor level during the award period with a specific goal of enhancing Scholar diversity through aggressive outreach and recruitment. The outcome of this program will be measured by the products of the Scholars' subsequent academic careers: external grant support, publications, and other contributions to basic and applied research in child health.

Public Health Relevance

The Child Health Research Center Development Award (CHRCDA) Program at CNHS will train the next generation of pediatrician-scientists who will perform cutting edge basic and applied research on issues of importance to child health and development. While there are many opportunities to use molecular biology to advance treatment of pediatric diseases, the technology is complex, labor intensive and requires a comprehensive understanding of current scientific advances. Because the necessary extended bench experience is often lacking in the traditional career development of most academic pediatricians who have recently completed clinical training, the CHRCDA provides 2-4 years of training and practical experience under the direction of experienced investigator-mentors.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HD001399-19
Application #
9616292
Study Section
Special Emphasis Panel (ZHD1)
Program Officer
Bremer, Andrew
Project Start
2001-09-25
Project End
2020-11-30
Budget Start
2018-12-01
Budget End
2019-11-30
Support Year
19
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Children's Research Institute
Department
Type
DUNS #
143983562
City
Washington
State
DC
Country
United States
Zip Code
20010
Nino, Cesar L; Perez, Geovanny F; Isaza, Natalia et al. (2018) Characterization of Sex-Based Dna Methylation Signatures in the Airways During Early Life. Sci Rep 8:5526
Megalaa, Rosemary; Perez, Geovanny F; Kilaikode-Cheruveettara, Sasikumar et al. (2018) Clinical definition of respiratory viral infections in young children and potential bronchiolitis misclassification. J Investig Med 66:46-51
Gerber, Daniel; Forster, Catherine S; Hsieh, Michael (2018) The Role of the Genitourinary Microbiome in Pediatric Urology: a Review. Curr Urol Rep 19:13
Pérez-Losada, Marcos; Authelet, Kayla J; Hoptay, Claire E et al. (2018) Pediatric asthma comprises different phenotypic clusters with unique nasal microbiotas. Microbiome 6:179
Forster, Catherine S; Jackson, Elizabeth; Ma, Qing et al. (2018) Predictive ability of NGAL in identifying urinary tract infection in children with neurogenic bladders. Pediatr Nephrol 33:1365-1374
Rodriguez-Martinez, Carlos E; Sossa-Briceño, Monica P; Nino, Gustavo (2018) Systematic review of instruments aimed at evaluating the severity of bronchiolitis. Paediatr Respir Rev 25:43-57
Forster, Catherine S; Shaikh, Nader; Hoberman, Alejandro et al. (2018) Uropathogens and Pyuria in Children With Neurogenic Bladders. Pediatrics 141:
Val, Stéphanie; Jeong, Stephanie; Poley, Marian et al. (2017) Purification and characterization of microRNAs within middle ear fluid exosomes: implication in otitis media pathophysiology. Pediatr Res 81:911-918
Rodríguez-Martínez, Carlos E; Sossa-Briceño, Monica P; Nino, Gustavo (2017) A systematic review of instruments aimed at evaluating metered-dose inhaler administration technique in children. J Asthma 54:173-185
Zhao, Hui Fen; Abraham, Allistair; Kim, Yoon-Sang et al. (2017) Lentiviral Transfer of ?-Globin with Fusion Gene NUP98-HOXA10HD Expands Hematopoietic Stem Cells and Ameliorates Murine ?-Thalassemia. Mol Ther 25:593-605

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