The Department of Pediatrics of the University of Utah proposes the continuation of its highly successful training program?the Utah Child Health Research Career Development Award (CHRCDA) program. The Utah CHRCDA selects the most outstanding junior faculty scholars for rigorous scientific training in a robust research environment. The Utah CHRCDA uses experienced basic- and physician-scientists as mentors to provide the expertise, guidance, and laboratoryfacilities that enable scholars to launch successful careers as physician-scientists. The overarching theme of the Utah CHRCDA, the genetic and developmental mechanisms that underlie pediatric disease, offers rich opportunities for research and discovery that will lead to improved health for children. Highly-promising scholars are selected from graduating fellows who join the Department, by faculty recruitment or from current junior faculty. Mentored experiences in the laboratories of established, NIH-funded investigators enable scholars to apply innovative research methods to molecular genetics and developmental biology. A structured curriculum (supported by a K30 award to the University's School of Medicine) offers scholars a graduate-level didactic education in epidemiology, biostatistics, data management, medical genetics, and molecular biology. Senior pediatric faculty members provide formal instruction in scientific writing, grant writing and research ethics. Utah scholars have made exceptional progress during the first four years of the current CHRCDA program. Four of the first six scholars received K series awards;one scholar has received an R21 award;and one scholar has a pending resubmission of a K08 application. These results indicate that the resources entrusted to the University of Utah and the Department of Pediatrics have been used effectively to mentor the research careers of young faculty members and fulfill the goals of the CHRCDA program.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Physician Scientist Award (Program) (PSA) (K12)
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Special Emphasis Panel (ZHD1-DSR-A (12))
Program Officer
Winer, Karen
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University of Utah
Schools of Medicine
Salt Lake City
United States
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Schober, Michelle E; Requena, Daniela F; Davis, Lizeth J et al. (2014) Alpha II Spectrin breakdown products in immature Sprague Dawley rat hippocampus and cortex after traumatic brain injury. Brain Res 1574:105-12
Zielinski, Brandon A; Prigge, Molly B D; Nielsen, Jared A et al. (2014) Longitudinal changes in cortical thickness in autism and typical development. Brain 137:1799-812
Schober, Michelle E; Requena, Daniela F; Block, Benjamin et al. (2014) Erythropoietin improved cognitive function and decreased hippocampal caspase activity in rat pups after traumatic brain injury. J Neurotrauma 31:358-69
Butterfield, Russell J; Stevenson, Tamara J; Xing, Lingyan et al. (2014) Congenital lethal motor neuron disease with a novel defect in ribosome biogenesis. Neurology 82:1322-30
Chen, Karin; Coonrod, Emily M; Kumanovics, Attila et al. (2013) Germline mutations in NFKB2 implicate the noncanonical NF-*B pathway in the pathogenesis of common variable immunodeficiency. Am J Hum Genet 93:812-24
Butterfield, Russell J; Foley, A Reghan; Dastgir, Jahannaz et al. (2013) Position of glycine substitutions in the triple helix of COL6A1, COL6A2, and COL6A3 is correlated with severity and mode of inheritance in collagen VI myopathies. Hum Mutat 34:1558-67
Zayachkivsky, A; Lehmkuhle, M J; Fisher, J H et al. (2013) Recording EEG in immature rats with a novel miniature telemetry system. J Neurophysiol 109:900-11
Schober, Michelle Elena; Block, Benjamin; Requena, Daniela F et al. (2012) Developmental traumatic brain injury decreased brain derived neurotrophic factor expression late after injury. Metab Brain Dis 27:167-73
Fung, Camille; Ke, Xingrao; Brown, Ashley S et al. (2012) Uteroplacental insufficiency alters rat hippocampal cellular phenotype in conjunction with ErbB receptor expression. Pediatr Res 72:2-9
Lakhina, Vanisha; Marcaccio, Christina L; Shao, Xin et al. (2012) Netrin/DCC signaling guides olfactory sensory axons to their correct location in the olfactory bulb. J Neurosci 32:4440-56

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