Gender has complex and poorly understood effects on health throughout the different phases of life. The mechanisms underlying the unique course of several diseases affecting women remain unclear in part because of longstanding impediments to research efforts involving different disciplines. The long-term objective of this application, supporting the Building Interdisciplinary Research Careers in Women's Health (BIRCWH) Program at Washington University, is to produce independent investigators conducting interdisciplinary research in women's health. The application has a single specific aim: To identify outstanding young scientists committed to women's health who have completed fellowship training, match them with mentors working in an environment that promotes interdisciplinary research, and provide them with career development experiences leading to their independence. During the past 10 years, the Washington University BIRCWH Program has successfully achieved this aim through a combination of a mentored research experience (utilizing outstanding mentors representing a broad research base encompassing most of the diseases that differentially affect women), didactic training, interaction with scientists from other disciplines pursuing problems in women's health, establishing a visiting scientist program, and formalizing interdisciplinary research links with a substantial number of clinical programs in women's health. The Program now proposes to extend this foundation of success by refining the didactic portion of the experience to make it even more relevant for Scholars by coordinating the coursework with that offered by the CTSA at Washington University, reshaping our mentor pool in order to enhance the interdisciplinary character of the program, integrating the Program with the newly created Center for Women's Infection Disease Research (CWIDR) at Washington University, and adding a peer-to-peer mentoring component. Our program has the potential to help fulfill the mission of NIH and ORWH by continuing to train outstanding scholars and serving as a focal point for paradigm-shifting research in women's health.

Public Health Relevance

By bridging fellowship training and independent faculty status, the BIRCWH program has the potential to significantly impact women's health by increasing the number of outstanding scientists utilizing novel and cooperative approaches to address problems that include depression, osteoporosis, lupus, type 2 diabetes, urinary tract infections, heart attacks, certain cancers, and infertility.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Physician Scientist Award (Program) (PSA) (K12)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-PSE-H (50))
Program Officer
Davis Nagel, Joan
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Washington University
Internal Medicine/Medicine
Schools of Medicine
Saint Louis
United States
Zip Code
Ghoshal, Nupur; Perry, Arie; McKeel, Daniel et al. (2015) Variably Protease-sensitive Prionopathy in an Apparent Cognitively Normal 93-Year-Old. Alzheimer Dis Assoc Disord 29:173-6
Chaturvedi, Kaveri S; Hung, Chia S; Giblin, Daryl E et al. (2014) Cupric yersiniabactin is a virulence-associated superoxide dismutase mimic. ACS Chem Biol 9:551-61
Liang, Stephen Y; Theodoro, Daniel L; Schuur, Jeremiah D et al. (2014) Infection prevention in the emergency department. Ann Emerg Med 64:299-313
Liang, S Y; Khair, H N; McDonald, J R et al. (2014) Daptomycin versus vancomycin for osteoarticular infections due to methicillin-resistant Staphylococcus aureus (MRSA): a nested case-control study. Eur J Clin Microbiol Infect Dis 33:659-64
Lane, Michael A; Marschall, Jonas; Beekmann, Susan E et al. (2014) Outpatient parenteral antimicrobial therapy practices among adult infectious disease physicians. Infect Control Hosp Epidemiol 35:839-44
Marschall, J; Lewis, J W S; Warren, D K et al. (2014) Baseline hypovitaminosis D is not associated with poor clinical outcomes in osteoarticular infections. Int J Infect Dis 26:98-102
Buchan, Jillian G; Alvarado, David M; Haller, Gabe et al. (2014) Are copy number variants associated with adolescent idiopathic scoliosis? Clin Orthop Relat Res 472:3216-25
Hung, Chia; Marschall, Jonas; Burnham, Carey-Ann D et al. (2014) The bacterial amyloid curli is associated with urinary source bloodstream infection. PLoS One 9:e86009
Echaiz, J F; Henderson, J P; Warren, D K et al. (2014) Weekend diagnosis of Escherichia coli urinary tract infection does not predict poor outcome. Epidemiol Infect 142:1422-4
Marschall, Jonas; Carpenter, Christopher R; Fowler, Susan et al. (2013) Antibiotic prophylaxis for urinary tract infections after removal of urinary catheter: meta-analysis. BMJ 346:f3147

Showing the most recent 10 out of 56 publications