Abstract

description): This is a application for the continued support of the Center of Excellence in Child Health at Washington University School of Medicine. The scientific focus of our Center is to develop and utilize genetic models of human disease states in transgenic and knockout mice. The long-term goal of the Center is to develop Scholars in human developmental biology. This goal is achieved by applying the recent advances in cell, molecular and developmental biology to an understanding of the pathogenesis and treatment of a broad spectrum of diseases within the Pediatric arena. In order to accomplish this established areas of investigative strength of Washington University School of Medicine and the Department of Pediatrics with basic and applied developmental biology will be combined. The Center will continue to utilize the core facility for the generation of animal models of human disease states via new and evolving state-of-the-art technologies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
2K12HD001487-06
Application #
6204725
Study Section
Special Emphasis Panel (ZHD1-MCHG-B (10))
Program Officer
Grave, Gilman D
Project Start
1996-02-15
Project End
2005-11-30
Budget Start
2001-03-12
Budget End
2001-11-30
Support Year
6
Fiscal Year
2001
Total Cost
$410,400
Indirect Cost

  Institution

Name
Washington University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Middleton, Jason W; Simons, Daniel J; Simmons, Jennifer W et al. (2017) Long-Term Deficits in Cortical Circuit Function after Asphyxial Cardiac Arrest and Resuscitation in Developing Rats. eNeuro 4:
Zhou, Julie Y; Isaacson-Schmid, Megan; Utterson, Elizabeth C et al. (2015) Prevalence of nasopharyngeal pneumococcal colonization in children and antimicrobial susceptibility profiles of carriage isolates. Int J Infect Dis 39:50-52
Deady, Lauren E; Todd, Elizabeth M; Davis, Chris G et al. (2014) L-plastin is essential for alveolar macrophage production and control of pulmonary pneumococcal infection. Infect Immun 82:1982-93
Kozel, Beth A; Bayliss, Susan J; Berk, David R et al. (2014) Skin findings in Williams syndrome. Am J Med Genet A 164A:2217-25
Kozel, Beth A; Su, Chi-Ting; Danback, Joshua R et al. (2014) Biomechanical properties of the skin in cutis laxa. J Invest Dermatol 134:2836-2838
Kozel, Beth A; Danback, Joshua R; Waxler, Jessica L et al. (2014) Williams syndrome predisposes to vascular stiffness modified by antihypertensive use and copy number changes in NCF1. Hypertension 63:74-9
Keppel, Molly P; Yang, Liping; Cooper, Megan A (2013) Murine NK cell intrinsic cytokine-induced memory-like responses are maintained following homeostatic proliferation. J Immunol 190:4754-62
Morley, Sharon Celeste (2013) The actin-bundling protein L-plastin supports T-cell motility and activation. Immunol Rev 256:48-62
Todd, Elizabeth M; Deady, Lauren E; Morley, Sharon Celeste (2013) Intrinsic T- and B-cell defects impair T-cell-dependent antibody responses in mice lacking the actin-bundling protein L-plastin. Eur J Immunol 43:1735-44
Mitra, Riddhi; Nogee, Daniel P; Zechner, Juliet F et al. (2012) The transcriptional coactivators, PGC-1? and ?, cooperate to maintain cardiac mitochondrial function during the early stages of insulin resistance. J Mol Cell Cardiol 52:701-10

Showing the most recent 10 out of 58 publications