This application is a competitive renewal for our Child Health Research Career Development Award (CHRCDA), which has established a unique nexus of excellence for the enhancement of basic, translational, and clinical research training and career development in pediatrics. This long-standing career development program, designed to guide junior faculty during their transition to independent research careers in pediatric medicine, is now in its twentieth year at Cincinnati Children's Hospital Medical Center (CCHMC), with this being our fourth renewal application. Our CHRCDA has supported 42 CHRCDA Scholars at our institution, many of whom have become national leaders in academic pediatrics. Collectively, our Scholars have published over 1,400 peer-reviewed publications and been awarded over $81 million in direct grant funding and 41 NIH R01 grants. The CCHMC CHRCDA Program synergizes with our other innovative, established programs for research training including the Procter Scholar Program and the NIH Clinical and Translational Science Award (CTSA), especially its KL2 component, as well as with an array of NIH-funded research programs. In contrast to these programs, our CHRCDA Program specifically targets pediatricians and has the advantage of offering training and career development across a wide array of disciplines and specialties in basic, translational, and clinical research. Our CHRCDA Program identifies and recruits promising young pediatric faculty. A CCHMC physician scientist typically completes a 3- to 5-year track in research training and career development and is provided mentorship from 1 or more senior faculty. For our CHRCDA Scholars, generally 2 years of this track are funded by the CHRCDA, and the provided scientific guidance by our exceptional and highly committed CHRCDA primary faculty mentors is complemented by additional curricula, seminars, and resources. Specific aspects of the Program are customized based on the individual needs of the Scholar, especially their prior experiences and current competencies. The present CCHMC CHRCDA Program, under direction of the Principal Investigator, Program Director, and its Administrative Core, has drawn together established investigators with excellence in pediatric science and mentoring at CCHMC and the University of Cincinnati College of Medicine (UCCOM) to serve as primary mentors for the pediatric physician scientists during their transition to independence. The Program's Administrative Core identifies candidates, monitors the overall career development of our Scholars, and provides support for recruitment efforts at local and national levels, prioritizing Scholar recruitment from underrepresented groups. The CCHMC CHRCDA Program's combination of individual mentorship, advanced training, and research-conducive environment and resources (e.g. CCHMC Research Cores) is a needed and successful strategy to enhance the research productivity and independence of our pediatric physician scientists as they begin their academic careers in pediatric medicine.

Public Health Relevance

The CCHMC CHRCDA Program seeks to enhance the professional development, research capability, and interest of young pediatric physician scientists who seek a full-time career in research with a major interest in pediatrics. The objective is to equip these young faculty who are just starting their careers in academic pediatrics with the skills necessary to succeed in meaningful, independent scientific careers in academic medicine. We aim to train the next generation of leaders in academic pediatrics.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HD028827-22
Application #
8389906
Study Section
Special Emphasis Panel (ZHD1-DSR-N (53))
Program Officer
Winer, Karen
Project Start
2002-02-20
Project End
2016-11-30
Budget Start
2012-12-01
Budget End
2013-11-30
Support Year
22
Fiscal Year
2013
Total Cost
$294,994
Indirect Cost
$31,897
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
Du, Wei; Erden, Ozlem; Wilson, Andrew et al. (2014) Deletion of Fanca or Fancd2 dysregulates Treg in mice. Blood 123:1938-47
Sharma, Akshay; Myers, Kasiani; Ye, Zhan et al. (2014) Dyskeratosis congenita caused by a novel TERT point mutation in siblings with pancytopenia and exudative retinopathy. Pediatr Blood Cancer 61:2302-4
Valentine, Christina J; Schlaudecker, Elizabeth P (2014) 50 years ago in the Journal of Pediatrics: poliomyelitis antibodies in human colostrum and milk. J Pediatr 164:82
Lyons, Jonathan J; Sun, Guangping; Stone, Kelly D et al. (2014) Mendelian inheritance of elevated serum tryptase associated with atopy and connective tissue abnormalities. J Allergy Clin Immunol 133:1471-4
Jodele, Sonata; Davies, Stella M; Lane, Adam et al. (2014) Diagnostic and risk criteria for HSCT-associated thrombotic microangiopathy: a study in children and young adults. Blood 124:645-53
Liu, Sheng; Young, Sarah Marie; Varisco, Brian Michael (2014) Dynamic expression of chymotrypsin-like elastase 1 over the course of murine lung development. Am J Physiol Lung Cell Mol Physiol 306:L1104-16
Ringdén, Olle; Brazauskas, Ruta; Wang, Zhiwei et al. (2014) Second solid cancers after allogeneic hematopoietic cell transplantation using reduced-intensity conditioning. Biol Blood Marrow Transplant 20:1777-84
Moncrief, Terri; Beck, Andrew F; Simmons, Jeffrey M et al. (2014) Single parent households and increased child asthma morbidity. J Asthma 51:260-6
Minar, Phillip; Haberman, Yael; Jurickova, Ingrid et al. (2014) Utility of neutrophil Fc? receptor I (CD64) index as a biomarker for mucosal inflammation in pediatric Crohn's disease. Inflamm Bowel Dis 20:1037-48
Schlaudecker, Elizabeth P; Heck, Joan P; MacIntyre, Elizabeth T et al. (2014) Comparison of a new transport medium with universal transport medium at a tropical field site. Diagn Microbiol Infect Dis 80:107-10

Showing the most recent 10 out of 41 publications