The Iowa Women's Reproductive Health Research Career Development Center, the Department of Obstetrics and Gynecology at the Carver College of Medicine, the University of Iowa, is an outstanding site to house a Women's Reproductive Health Research (WRHR) Career Development Center. This application draws upon the following specific strengths: (1) the exceptional research milieu and infrastructure as well as the national prominence of the University of Iowa Carver College of Medicine in research and education, (2) a successful model of research career development for young faculty that is already in place, (3) established and successful research themes in women's health in the department of obstetrics and gynecology and throughout the college of medicine, (4) an already existing strategic research plan that will be integrated into the WRHR Center, (5) an experienced and highly qualified Principal Investigator, Kimberly Leslie, M.D. (former WRHR Program Director at the University of Colorado and an AAOGF and RSDP scholar), and an acclaimed scientist and teacher, Mario Ascoli, Ph.D., who will serve as the Research Director, (6) an impressive cadre of senior scientists and leaders from the department and throughout the college who will serve as mentors and advisors, (7) a broad based applicant pool from which to recruit with an emphasis on an innovative mini-sabbatical program to recruit scholars from underrepresented groups, and (8) very strong institutional support that will contribute to our success. Two research tracts (basic and clinical) and six programmatic themes, chosen because Iowa has world class research in these fields, are supported by the University of Iowa WRHR. The research themes are (1) cancer and hormones, (2) epidemiology of reproductive disorders, (3) genetics and genomics, (4) hormones and signaling, (5) host defense, and (6) hypertension and the vasculature. A well-integrated WRHR Program that supports both basic and clinical-epidemiologic investigation is in place. Scholars will benefit from pertinent didactic coursework along with intensive training in the finest basic and clinical laboratories throughout the institution. The University of Iowa proposed WRHR has all of the components to meet the ultimate goal of the program, to develop a successful cadre of academic investigators who will excel in research and expand the frontiers of knowledge in women's reproductive health going into the future.

Public Health Relevance

Women's reproductive health research has been stymied by a lack of trained physician scientists to enhance discovery in this important area of science. Research to ensure the best reproductive outcomes is critical to the survival of our species. The Women's Reproductive Health Research Career Development Center at the University of Iowa is now poised to recruit and train the physician investigators of the future in this field.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HD063117-04
Application #
8323501
Study Section
Special Emphasis Panel (ZHD1-DSR-L (14))
Program Officer
Parrott, Estella C
Project Start
2009-09-30
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
4
Fiscal Year
2012
Total Cost
$475,200
Indirect Cost
$35,200
Name
University of Iowa
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
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Reyes, Henry D; Carlson, Matthew J; Devor, Eric J et al. (2016) Downregulation of FOXO1 mRNA levels predicts treatment failure in patients with endometrial pathology conservatively managed with progestin-containing intrauterine devices. Gynecol Oncol 140:152-60
Devor, Eric J; Schickling, Brandon M; Reyes, Henry D et al. (2016) Cullin-5, a ubiquitin ligase scaffold protein, is significantly underexpressed in endometrial adenocarcinomas and is a target of miR-182. Oncol Rep 35:2461-5
Waite, Courtney; Mejia, Rachel; Ascoli, Mario (2016) Gq/11-Dependent Changes in the Murine Ovarian Transcriptome at the End of Gestation. Biol Reprod 94:62
Kavlashvili, Tamar; Jia, Yichen; Dai, Donghai et al. (2016) Inverse Relationship between Progesterone Receptor and Myc in Endometrial Cancer. PLoS One 11:e0148912
Stegmann, Barbara J; Santillan, Mark; Leader, Benjamin et al. (2015) Changes in antimüllerian hormone levels in early pregnancy are associated with preterm birth. Fertil Steril 104:347-55.e3
Mejia, Rachel; Waite, Courtney; Ascoli, Mario (2015) Activation of Gq/11 in the mouse corpus luteum is required for parturition. Mol Endocrinol 29:238-46
Bender, David; Sill, Michael W; Lankes, Heather A et al. (2015) A phase II evaluation of cediranib in the treatment of recurrent or persistent endometrial cancer: An NRG Oncology/Gynecologic Oncology Group study. Gynecol Oncol 138:507-12
Ryan, Ginny L; Mengeling, Michelle A; Booth, Brenda M et al. (2014) Voluntary and involuntary childlessness in female veterans: associations with sexual assault. Fertil Steril 102:539-47
Dunkelberg, J C; Berkley, E M F; Thiel, K W et al. (2014) Hepatitis B and C in pregnancy: a review and recommendations for care. J Perinatol 34:882-91

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