Although some recognition of the unique aspects of the biology of the developing child clearly began in the 1800's, pediatrics did not evolve as an independent intellectual and clinical discipline until the 1900's. Only relatively recently have emerging molecular principles been systematically applied to the understanding and treatment of diseases of childhood. However, increasing emphasis on revenue generation, decreasing availability of institutional start-up funds for new investigators, and the individual's imperative for repayment of medical school debt have made it increasingly difficult to attract, foster, and maintain a cadre of individuals whose interests are in the development of a translational body of molecular and developmental pediatric knowledge. It is absolutely vital that we establish and nurture venues in which to train researchers at the interfaces between molecular and developmental biology and pediatrics. The present application proposes to take advantage of the high quality, interactive, and interdisciplinary faculty and environment of the University of Rochester to give clinically trained junior faculty the opportunity to engage in and understand basic, and translational research, develop in these fellows the thinking skills and knowledge base that will allow their application of basic molecular principles towards enhancing and developing our understanding of the developmental origins and mechanisms of childhood disease.

Public Health Relevance

The proposed program will train clinically oriented junior faculty to prepare them for and launch them in careers in molecular pediatrics research. This research will be aimed at understanding and treating diseases of childhood.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HD068373-04
Application #
8604168
Study Section
Special Emphasis Panel (ZHD1-DSR-N (12))
Program Officer
Winer, Karen
Project Start
2010-12-25
Project End
2015-11-30
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
4
Fiscal Year
2014
Total Cost
$432,000
Indirect Cost
$32,000
Name
University of Rochester
Department
Pediatrics
Type
Schools of Dentistry
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Scheible, Kristin M; Emo, Jason; Laniewski, Nathan et al. (2018) T cell developmental arrest in former premature infants increases risk of respiratory morbidity later in infancy. JCI Insight 3:
Knapik, D M; Sanders, J O; Gilmore, A et al. (2018) A quantitative method for the radiological assessment of skeletal maturity using the distal femur. Bone Joint J 100-B:1106-1111
Baker, Joshua F; Newman, Anne B; Kanaya, Alka et al. (2018) The Adiponectin Paradox in the Elderly: Associations with Body Composition, Physical Functioning, and Mortality. J Gerontol A Biol Sci Med Sci :
Baker, Joshua F; Long, Jin; Leonard, Mary B et al. (2018) Estimation of Skeletal Muscle Mass Relative to Adiposity Improves Prediction of Physical Performance and Incident Disability. J Gerontol A Biol Sci Med Sci 73:946-952
Tesini, Brenda L; Wright, Terry W; Malone, Jane E et al. (2017) Immunization with Pneumocystis Cross-Reactive Antigen 1 (Pca1) Protects Mice against Pneumocystis Pneumonia and Generates Antibody to Pneumocystis jirovecii. Infect Immun 85:
Rezaee, Fariba; Harford, Terri J; Linfield, Debra T et al. (2017) cAMP-dependent activation of protein kinase A attenuates respiratory syncytial virus-induced human airway epithelial barrier disruption. PLoS One 12:e0181876
Gonzalez Ballesteros, Luisa F; Ma, Nina S; Gordon, Rebecca J et al. (2017) Unexpected widespread hypophosphatemia and bone disease associated with elemental formula use in infants and children. Bone 97:287-292
Weber, D R; Stark, L J; Ittenbach, R F et al. (2017) Building better bones in childhood: a randomized controlled study to test the efficacy of a dietary intervention program to increase calcium intake. Eur J Clin Nutr 71:788-794
Baker, Joshua F; Giles, Jon T; Weber, David et al. (2017) Assessment of muscle mass relative to fat mass and associations with physical functioning in rheumatoid arthritis. Rheumatology (Oxford) 56:981-988
Weber, David R; O'Brien, Kimberly O; Schwartz, George J (2017) Evidence of disordered calcium metabolism in adolescent girls with type 1 diabetes: An observational study using a dual-stable calcium isotope technique. Bone 105:184-190

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