Although some recognition of the unique aspects of the biology of the developing child clearly began in the 1800's, pediatrics did not evolve as an independent intellectual and clinical discipline until the 1900's. Only relatively recently have emerging molecular principles been systematically applied to the understanding and treatment of diseases of childhood. However, increasing emphasis on revenue generation, decreasing availability of institutional start-up funds for new investigators, and the individual's imperative for repayment of medical school debt have made it increasingly difficult to attract, foster, and maintain a cadre of individuals whose interests are in the development of a translational body of molecular and developmental pediatric knowledge. It is absolutely vital that we establish and nurture venues in which to train researchers at the interfaces between molecular and developmental biology and pediatrics. The present application proposes to take advantage of the high quality, interactive, and interdisciplinary faculty and environment of the University of Rochester to give clinically trained junior faculty the opportunity to engage in and understand basic, and translational research, develop in these fellows the thinking skills and knowledge base that will allow their application of basic molecular principles towards enhancing and developing our understanding of the developmental origins and mechanisms of childhood disease.

Public Health Relevance

The proposed program will train clinically oriented junior faculty to prepare them for and launch them in careers in molecular pediatrics research. This research will be aimed at understanding and treating diseases of childhood.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HD068373-04
Application #
8604168
Study Section
Special Emphasis Panel (ZHD1-DSR-N (12))
Program Officer
Winer, Karen
Project Start
2010-12-25
Project End
2015-11-30
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
4
Fiscal Year
2014
Total Cost
$432,000
Indirect Cost
$32,000
Name
University of Rochester
Department
Pediatrics
Type
Schools of Dentistry
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Knowlden, Sara A; Capece, Tara; Popovic, Milan et al. (2014) Regulation of T cell motility in vitro and in vivo by LPA and LPA2. PLoS One 9:e101655
Georas, Steve N; Rezaee, Fariba (2014) Epithelial barrier function: at the front line of asthma immunology and allergic airway inflammation. J Allergy Clin Immunol 134:509-20
Rezaee, Fariba; Georas, Steve N (2014) Breaking barriers. New insights into airway epithelial barrier function in health and disease. Am J Respir Cell Mol Biol 50:857-69
Nayak, Jennifer L; Alam, Shabnam; Sant, Andrea J (2013) Cutting edge: Heterosubtypic influenza infection antagonizes elicitation of immunological reactivity to hemagglutinin. J Immunol 191:1001-5
Chapman, Timothy J; Emo, Jason A; Knowlden, Sara A et al. (2013) Pre-existing tolerance shapes the outcome of mucosal allergen sensitization in a murine model of asthma. J Immunol 191:4423-30
Nayak, Jennifer L; Fitzgerald, Theresa F; Richards, Katherine A et al. (2013) CD4+ T-cell expansion predicts neutralizing antibody responses to monovalent, inactivated 2009 pandemic influenza A(H1N1) virus subtype H1N1 vaccine. J Infect Dis 207:297-305
Rezaee, Fariba; DeSando, Samantha A; Ivanov, Andrei I et al. (2013) Sustained protein kinase D activation mediates respiratory syncytial virus-induced airway barrier disruption. J Virol 87:11088-95
Chaves, Francisco A; Lee, Alvin H; Nayak, Jennifer L et al. (2012) The utility and limitations of current Web-available algorithms to predict peptides recognized by CD4 T cells in response to pathogen infection. J Immunol 188:4235-48