Duke University Medical Center (Duke) and the University of North Carolina at Chapel Hill (UNC) jointly propose this competing renewal of our Clinical Hematology and Transfusion Medicine Research Career Development Program in response to the National Heart, Lung and Blood Institute RFA-HL-12-005. Duke and UNC have long traditions of collaborative basic and clinical research in hematology. We now propose to continue our program to train scholars in four Clinical Research Focus Areas that are well established strengths of our medical center, namely: (1) Sickle Cell Disease;(2) Thrombosis and Thrombophilia;(3) Disorders of Hemostasis;and (4) Transfusion Medicine, Anemia, and Stem Cell Therapy. The purpose of the present application is therefore to ensure the continuation of high quality patient-oriented research training at Duke and UNC through the provision of a clinical, didactic and experiential program for scholars who are committed to academic clinical research careers focusing on hematology and transfusion medicine. This K12 Career Development Program will include a didactic and clinical curriculum designed to teach scholars the broad array of skills needed to perform clinical research and to establish successful academic research careers in hematology or transfusion medicine. Each scholar will have the opportunity to earn a master's degree in clinical research, and there are also extensive course offerings in genomics and genetics. In addition, we propose four primary research tracks that our trainees can enter for their mentored research experience. Each has at least two Lead Mentors, and there are numerous faculty at Duke and UNC who will serve as co-mentors. Our 4 tracks are (1) Translational Research, (2) Genetics and Pharmacogenetics;(3) Clinical Trials;and (4) Health Services Research/Outcomes/Health Policy. This combination of clinical and didactic training and a multidisciplinary mentored research experience will prepare scholars for submission of applications for extramural funding for their ongoing research program and for successful negotiation of their research careers. The long-range goal of this program is thereby to help ensure an adequate supply of well trained researchers who will be able to confront the clinical problems of hematology and transfusion medicine through well-designed, skillfully conducted and multidisciplinary clinical research.
This career development program will provide translational and clinical research training to physician-scientists focused on problems related to hematologic diseases and their treatment, including transfusion medicine and cellular therapy, including hematopoietic stem cell transplantation. Advances in these fields and more physicians capable of leading those advances are needed in order to improve the health of millions of people with inherited and acquired blood disorders.
|Mooberry, M J; Bradford, R; Hobl, E L et al. (2016) Procoagulant microparticles promote coagulation in a factor XI-dependent manner in human endotoxemia. J Thromb Haemost 14:1031-42|
|Mooberry, Micah J; Key, Nigel S (2016) Microparticle analysis in disorders of hemostasis and thrombosis. Cytometry A 89:111-22|
|Folsom, A R; Tang, W; Roetker, N S et al. (2015) Prospective study of sickle cell trait and venous thromboembolism incidence. J Thromb Haemost 13:2-9|
|Amin, Chirag; Adam, Soheir; Mooberry, Micah J et al. (2015) Coagulation activation in sickle cell trait: an exploratory study. Br J Haematol 171:638-46|
|Byrnes, James R; Duval, CÃ©dric; Wang, Yiming et al. (2015) Factor XIIIa-dependent retention of red blood cells in clots is mediated by fibrin Î±-chain crosslinking. Blood 126:1940-8|
|Caughey, Melissa C; Loehr, Laura R; Key, Nigel S et al. (2014) Sickle cell trait and incident ischemic stroke in the Atherosclerosis Risk in Communities study. Stroke 45:2863-7|
|Lee, Taewoo; Biddle, Andrea K; Lionaki, Sofia et al. (2014) Personalized prophylactic anticoagulation decision analysis in patients with membranous nephropathy. Kidney Int 85:1412-20|
|Derebail, Vimal K; Lacson Jr, Eduardo K; Kshirsagar, Abhijit V et al. (2014) Sickle trait in African-American hemodialysis patients and higher erythropoiesis-stimulating agent dose. J Am Soc Nephrol 25:819-26|
|Laurin, Louis-Philippe; Nachman, Patrick H; Desai, Payal C et al. (2014) Hydroxyurea is associated with lower prevalence of albuminuria in adults with sickle cell disease. Nephrol Dial Transplant 29:1211-8|
|Shah, Nirmish; Rollins, Margo; Landi, Daniel et al. (2014) Differences in pain management between hematologists and hospitalists caring for patients with sickle cell disease hospitalized for vasoocclusive crisis. Clin J Pain 30:266-8|
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