Stanford Career Development Program in Omics of Lung Diseases (K12). We propose a Career Development Program (CDP) in Omics of lung diseases with a major focus on pulmonary arterial hypertension (PAH). This is a logical extension of our current K12 CDP on the "Genetics and Genomics of Lung Diseases" that focuses on PAH. The new CDP proposal allows us to equip the next cadre of MD and PhD scientists with interdisciplinary and bioinformatic skills to integrate new high throughput genomic, proteomic and metabolomic platforms to gain a better understanding of disease pathophysiology. This proposed CDP in Omics will fuel the major cross-departmental collaborations we have built through NIH- NHLBI Interdisciplinary grants focusing on PAH. One of our NIH sponsored projects applies novel cutting-edge high-throughput proteomic methodologies to investigate inflammatory cells in autoimmune and idiopathic PAH. Another utilizes genomics and bioinformatics and induced pluripotent stem cell methodology to relate gene variants, methylation changes and RNA expression differences across the genome, to the functional behavior of native and iPSC-derived endothelial cells from PAH patients. Our role in the Pulmonary Hypertension Breakthrough Initiative Network permits access to these valuable samples, and our major clinical programs in Adult and Pediatric PAH assure that we are well-positioned to train a new generation of young scientists in this important area of research. Our Scholars will have MD or PhD backgrounds and our CDP offers extensive didactic cross training in the omics (genomics, proteomics, and metabolomics) and in computational biology, particularly for the MD with little background preparation in these areas. As well, we offer training in lung vascular anatomy, physiology and pathology for the PhD Scholar with little exposure to medicine. Each Scholar will undertake a mentored research project beginning in the first year of training, with a primary Mentor who has expertise in PAH, in the Omics fields, or in Bioinformatics, and two Co-Mentors with the complementary skills. Mentors and Co-Mentors will help the Scholar attain those skills that facilitate interpreting the large data sets resulting fro high throughput research to uncover the biological and clinical relevance of the findings. Our CDP focuses on one disease but, at the same time, provides the Scholar with the necessary tools to take on the challenges of future high throughput scientific discovery, to improve diagnosis and treatment of many other lung diseases.

Public Health Relevance

Stanford Career Development Program in ?Omics? of Lung Diseases (K12) Narrative: We propose a career development program (CDP) for MD and PhD postodoctoral Scholars in the ?Omics? of lung disease that focuses on the pathobiology of pulmonary arterial hypertension (PAH). In our CDP we provide Scholars with a team of Mentor and two Co-Mentors that have complementary expertise in PAH, Bioinformatics and ?Omics? to guide the research project. We cross train the Scholars in genetics, epigenetics, proteomics, metabolism and bioinformatics as well as in lung physiology and pathology, through advanced courses, seminars and workshops.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Physician Scientist Award (Program) (PSA) (K12)
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Special Emphasis Panel (ZHL1-CSR-J (M1))
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Colombini-Hatch, Sandra
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Stanford University
Schools of Medicine
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Chung, Lorinda; Farber, Harrison W; Benza, Raymond et al. (2014) Unique predictors of mortality in patients with pulmonary arterial hypertension associated with systemic sclerosis in the REVEAL registry. Chest 146:1494-504
Nicolls, Mark R; Laubach, Victor E (2014) Traumatic brain injury: lungs in a RAGE. Sci Transl Med 6:252fs34