The Division of Neurology at the Children's National Medical Center (CNMC) proposes a Neurological Sciences Academic Developmental (NSADA) training program to support the career development of pediatric neurologists, leading to research independence. The program promotes clinical, basic, and translational research skills of trainees entering child neurology, encourages these promising young child neurologists to focus their efforts on important problems in child neurology, and develops young investigators who will become future leaders in pediatric neurology research and be able to successfully compete for extramural grant support. This NSADA training grant will focus on pediatric neurologic disorders where CNMC has well established multidisciplinary expertise, including neuro-oncologic diseases, epilepsy, and neurogenetics. The program outlined has a highly integrated, carefully developed didactic training program focused on basic information needed for a successful academic career, including training in human subjects' protection, research knowledge and proficiency development, research methodology, and research experience using state-of-the-art core facilities available at CNMC. The second phase of training includes focused research activities supported by mentors selected for their willingness to be part of this effort, and their past accomplishments including proven ability to pursue research in important areas of childhood neuroscience and a record of past effective mentorship. CNMC has extensive experience in developing and implementing individual or institutional career development awards, including those in neuroscience. Candidates who are potential applicants are already in place in the CNMC Neurology Fellowship Program and applicants from other institutions will be sought. The Department of Neurology, staffed by 21 neurologists, the majority of whom are pursuing academic research, has a strong training program, a proven record of developing academic child neurologists and has trained multiple minority fellows. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12NS052159-02
Application #
7276605
Study Section
NST-2 Subcommittee (NST)
Program Officer
Galpern, Wendy R
Project Start
2006-08-15
Project End
2011-07-31
Budget Start
2007-08-01
Budget End
2008-07-31
Support Year
2
Fiscal Year
2007
Total Cost
$269,190
Indirect Cost
Name
Children's Research Institute
Department
Type
DUNS #
143983562
City
Washington
State
DC
Country
United States
Zip Code
20010
Sepeta, Leigh N; Croft, Louise J; Zimmaro, Lauren A et al. (2015) Reduced language connectivity in pediatric epilepsy. Epilepsia 56:273-82
Wirrell, Elaine C; Shellhaas, Renée A; Joshi, Charuta et al. (2015) How should children with West syndrome be efficiently and accurately investigated? Results from the National Infantile Spasms Consortium. Epilepsia 56:617-25
Wilmshurst, Jo M; Gaillard, William D; Vinayan, Kollencheri Puthenveettil et al. (2015) Summary of recommendations for the management of infantile seizures: Task Force Report for the ILAE Commission of Pediatrics. Epilepsia 56:1185-97
Scafidi, Joseph; Hammond, Timothy R; Scafidi, Susanna et al. (2014) Intranasal epidermal growth factor treatment rescues neonatal brain injury. Nature 506:230-4
Jablonska, Beata; Scafidi, Joseph; Aguirre, Adan et al. (2012) Oligodendrocyte regeneration after neonatal hypoxia requires FoxO1-mediated p27Kip1 expression. J Neurosci 32:14775-93
Crawford, John R; Santi, Maria Rita; Cornelison, Robbie et al. (2009) Detection of human herpesvirus-6 in adult central nervous system tumors: predominance of early and late viral antigens in glial tumors. J Neurooncol 95:49-60
Crawford, John R; Zaninovic, Alejandra; Santi, Mariarita et al. (2009) Primary spinal cord tumors of childhood: effects of clinical presentation, radiographic features, and pathology on survival. J Neurooncol 95:259-69
Crawford, John R; Santi, Maria R; Thorarinsdottir, Halldora K et al. (2009) Detection of human herpesvirus-6 variants in pediatric brain tumors: association of viral antigen in low grade gliomas. J Clin Virol 46:37-42
Crawford, John R; MacDonald, Tobey J; Packer, Roger J (2007) Medulloblastoma in childhood: new biological advances. Lancet Neurol 6:1073-85
Crawford, John R; Kadom, Nadja; Santi, Maria Rita et al. (2007) Human herpesvirus 6 rhombencephalitis in immunocompetent children. J Child Neurol 22:1260-8

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