This is an application for a Mentored Patient-Oriented Research Development Award (K23). The goal of the proposed project is to provide the Applicant with advanced skills needed to establish an independent program of research in cognitive aging using neuroimaging and epidemiological methodologies. The Applicant proposes a comprehensive training plan, combining didactic instruction with established researchers;formal coursework;participation in ongoing seminars at Columbia University;and applied training experiences with individual advisors. Specific training goals include advanced knowledge and skill acquisition in the neurobiological mechanisms of cognitive aging;potential mediators and moderators of cognitive aging, including cerebrovascular risk factors and cross-cultural issues;design, implementation, and statistical analysis of epidemiological studies;principles of magnetic resonance imaging (MRI) and advanced neuromorphometric analysis;and the responsible conduct of research. The training plan will be executed in coordination with a proposed study that utilizes data from the Washington Heights Inwood Columbia Aging Project (WHICAP), an ongoing NIA funded study (P01AG007232) of risk factors for dementia in a multiethnic population of older adults residing in northern Manhattan. Although the main goal of WHICAP is to elucidate risk factors of Alzheimer's disease, it does not explicitly characterize neuromorphology or cognition in individuals who do not develop dementia. The proposed study will address the determinants of neuromorphology and related cognitive profiles among approximately 700 older individuals in the WHICAP cohort with """"""""normal"""""""" age-related cognitive function. The project will examine the association between chronological age and several measures of neuromorphology, including regional volumes, white matter hyperintensity burden, and a new multivariate approach for the characterization of age-associated patterns of gray and white matter. These measures will be related to baseline performance on neuropsychological tests and change in cognition following an 18-month period. A secondary goal will be to examine the mediating effect of cerebrovascular risk factors (i.e., hypertension, insulin resistance, obesity, and hypercholesterolemia) and ethnic group differences on neuromorphology. The proposed project aims will therefore elucidate neurobiological changes associated with aging and will serve as a bridge for the Applicant to establish an independent investigator career in conducting large- scale neuromorphometry studies on clinical populations.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23AG029949-04
Application #
7807912
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Wagster, Molly V
Project Start
2007-05-15
Project End
2012-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
4
Fiscal Year
2010
Total Cost
$150,242
Indirect Cost
Name
Columbia University (N.Y.)
Department
Neurology
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Last, Briana S; García Rubio, Maria-José; Zhu, Carolyn W et al. (2017) Medicare Expenditure Correlates of Atrophy and Cerebrovascular Disease in Older Adults. Exp Aging Res 43:149-160
Devanand, Davangere P; Lee, Seonjoo; Manly, Jennifer et al. (2015) Olfactory identification deficits and increased mortality in the community. Ann Neurol 78:401-11
Zahodne, Laura B; Manly, Jennifer J; Brickman, Adam M et al. (2015) Is residual memory variance a valid method for quantifying cognitive reserve? A longitudinal application. Neuropsychologia 77:260-6
Devanand, D P; Lee, Seonjoo; Manly, Jennifer et al. (2015) Olfactory deficits predict cognitive decline and Alzheimer dementia in an urban community. Neurology 84:182-9
Gu, Yian; Scarmeas, Nikolaos; Short, Erica Eaton et al. (2014) Alcohol intake and brain structure in a multiethnic elderly cohort. Clin Nutr 33:662-7
Brickman, Adam M; Schupf, Nicole; Manly, Jennifer J et al. (2014) APOE ?4 and risk for Alzheimer's disease: do regionally distributed white matter hyperintensities play a role? Alzheimers Dement 10:619-29
Noble, Kimberly G; Korgaonkar, Mayuresh S; Grieve, Stuart M et al. (2013) Higher education is an age-independent predictor of white matter integrity and cognitive control in late adolescence. Dev Sci 16:653-64
Willey, Joshua Z; Scarmeas, Nikolaos; Provenzano, Frank A et al. (2013) White matter hyperintensity volume and impaired mobility among older adults. J Neurol 260:884-90
Zahodne, Laura B; Manly, Jennifer J; Brickman, Adam M et al. (2013) Quantifying cognitive reserve in older adults by decomposing episodic memory variance: replication and extension. J Int Neuropsychol Soc 19:854-62
Zahodne, Laura B; Manly, Jennifer J; MacKay-Brandt, Anna et al. (2013) Cognitive declines precede and predict functional declines in aging and Alzheimer's disease. PLoS One 8:e73645

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