Older adults with multiple chronic diseases are at high risk for both disability and adverse clinical events, outcomes that can be improved with physical activity, but there have been no trials to establish physical activity recommendations or clinical guidelines for this vulnerable population. Older adults with high comorbidity are a rapidl expanding subgroup, and thus there is a pressing need to develop effective approaches to motivate maintenance of physical activity to improve outcomes. A recent randomized controlled trial conducted by the applicant and mentors established the efficacy of inducing positive affect-a feeling of happiness and well-being-in motivating physical activity in older adults with cardiovascular disease, but the effect was not sustained beyond six months in older adults with multiple chronic diseases. Additional data shows that participants with a Charlson Index e 3 who maintained low levels of activity for 1 year had significantly lower rates of major clinical event t 2 years. The candidate's long-term goal is to become an independent clinical investigator in geriatric behavioral medicine focused on improving the health and quality of life of older adults with multiple chronic illnesses. The overall objective of this project, which is the next step towad that goal, is to leverage the initial successes achieved by the Positive Affect Induction for Regular Exercise (PAIRE) intervention for long-term maintenance of physical activity, targeted specifically to older adults with multiple high-risk chronic diseases. The central hypothesis is tht a tailored PAIRE intervention, customized to address the unique and complex needs of older adults with a Charlson Index e 3, will lead to sustained increases physical activity when compared to an educational control, even among those who have interval medical events or high depressive symptoms.
Aim 1 is to adapt the PAIRE intervention to older adults with multiple high-risk chronic diseases. The approach will rest upon a novel and rigorous sequential mixed methods strategy to identify key psychosocial and clinical factors that mediate and moderate maintenance of physical activity in older adults with multiple high-risk chronic diseases, followed by focus groups with patients and community-based providers to assess the acceptability of potential intervention components.
Aim 2 is to pilot test the new PAIRE intervention that is specific to older adults with multiple high-risk chronic illnesses. This work s innovative because it will translate the benefits of a proven intervention focused on positive affect to increase physical activity in older adults with multiple high-risk chronic illnesses, one that is tailored to the clinical and psychosocial challenges of this particularly vulnerable population. This work is significant because an effective intervention promoting physical activity will improve outcomes for older adults with multiple high-risk chronic diseases, and currently one does not exist. This project is expected to have an important positive impact because it will result in a new validated PAIRE intervention, while both positioning the candidate to submit a competitive R01 application as Principal Investigator, and enabling a novel and clinically important trajectory of work in geriatric behavioral medicine.

Public Health Relevance

The proposed research is relevant to public health because 65% of older adults have multiple chronic diseases, which places them at high risk for both future disability and adverse clinical events. Physical activity can improve outcomes, yet most older adults with multiple chronic diseases do not exercise and many doctors do not recommend it because no interventions have been developed specifically for this growing subgroup. This proposal will translate the benefits of a proven intervention focused on induction of positive affect to increase physical activity, which will be tailored to address the clinical an psychosocial needs of older adults with multiple chronic diseases.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Mentored Patient-Oriented Research Career Development Award (K23)
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Special Emphasis Panel (ZAG1)
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Joseph, Lyndon
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Weill Medical College of Cornell University
Internal Medicine/Medicine
Schools of Medicine
New York
United States
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Czajkowski, Susan M; Powell, Lynda H; Adler, Nancy et al. (2015) From ideas to efficacy: The ORBIT model for developing behavioral treatments for chronic diseases. Health Psychol 34:971-82
Charlson, Mary E; De Moraes, C Gustavo; Liebmann, Jeffrey M et al. (2015) Author reply: To PMID 24869467. Ophthalmology 122:e15-6
Winston, Ginger J; Phillips, Erica G; Wethington, Elaine et al. (2015) Social network characteristics associated with weight loss among black and hispanic adults. Obesity (Silver Spring) 23:1570-6
Phillips-Caesar, Erica G; Winston, Ginger; Peterson, Janey C et al. (2015) Small Changes and Lasting Effects (SCALE) Trial: the formation of a weight loss behavioral intervention using EVOLVE. Contemp Clin Trials 41:118-28
Winston, Ginger; Phillips, Erica; Wethington, Elaine et al. (2015) The Relationship between Social Network Body Size and the Body Size Norms of Black and Hispanic Adults. Prev Med Rep 2:941-945
Charlson, Mary E; Loizzo, Joseph; Moadel, Alyson et al. (2014) Contemplative self healing in women breast cancer survivors: a pilot study in underserved minority women shows improvement in quality of life and reduced stress. BMC Complement Altern Med 14:349
Charlson, Mary E; Wells, Martin T; Peterson, Janey C et al. (2014) Mediators and moderators of behavior change in patients with chronic cardiopulmonary disease: the impact of positive affect and self-affirmation. Transl Behav Med 4:7-17
Waseem, Muhammad; Boutin-Foster, Carla; Robbins, Laura et al. (2014) Perspectives on bullying among children who present to the emergency department with behavioral misconduct: a qualitative study. Pediatr Emerg Care 30:793-7
Peterson, Janey C; Burnes, David P R; Caccamise, Paul L et al. (2014) Financial exploitation of older adults: a population-based prevalence study. J Gen Intern Med 29:1615-23
Charlson, Mary E; de Moraes, Carlos Gustavo; Link, Alissa et al. (2014) Nocturnal systemic hypotension increases the risk of glaucoma progression. Ophthalmology 121:2004-12

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