Delirium affects up to 80% of mechanically ventilated patients in the intensive care unit (ICU). Delirium duration and severity are independently associated with higher morbidity and mortality. Early identification of patients susceptible to prolonged delirium duration and higher delirium severity will help in instituting effective therapeutic interventions to reduce complications associated with delirium. A personalized approach utilizing biomarkers to identify vulnerable delirious patients prone to increased delirium duration and severity offers promise to curtail the disease burden. This proposal describes a career development plan that will enable Dr. Khan to develop expertise in patient-oriented translational clinical research by acquiring the necessary skills in biomarker technology, bio- informatics and biostatistics. The candidate will study serum biomarkers of inflammation, astrocyte activation and neuroprotection in the context of a large randomized clinical trial, the Pharmacological Management of Delirium (PMD) trial. Dr. Khan's proposed project is a cohort study embedded within the large trial benefiting from the diverse patient population, data acquisition resources, research personnel and other inherent strengths of an R01. The completion of the project will identify a unique set of candidate biomarkers for delirium duration and severity and will establish Dr. Khan as a neurocognitive critical care researcher. The proposed career development plan integrates;a) advanced coursework in molecular biology, biostatistics, and bioinformatics, b) participation in local/national meetings to develop expertise in translational research, c) a multidisciplinary mentored research experience, and d) a highly supportive research environment. This environment includes an internationally recognized NIH funded PMD Study Group, a distinguished Indiana University Center for Aging Research, a renowned Clinical and Translational Sciences Institute, and pioneers in Medical Informatics, the Regenstrief Institute. Overall, this career development award will ensure the necessary protected time required to advance the candidate's career in biomarker based translational critical care research. In addition, the award will provide critical support to guide future translational studies / R01 applications. Future studies will assess the impact of utilizing a personalized approach consisting of early identification of vulnerable delirious patients through serum biomarkers coupled with effective therapeutic interventions in decreasing the morbidity and mortality associated with ICU delirium.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Mentored Patient-Oriented Research Career Development Award (K23)
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Application #
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Wagster, Molly V
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Indiana University-Purdue University at Indianapolis
Internal Medicine/Medicine
Schools of Medicine
United States
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Lasiter, Sue; Oles, Sylwia K; Mundell, James et al. (2016) Critical Care Follow-up Clinics: A Scoping Review of Interventions and Outcomes. Clin Nurse Spec 30:227-37
Orman, Eric S; Perkins, Anthony; Ghabril, Marwan et al. (2015) The confusion assessment method for the intensive care unit in patients with cirrhosis. Metab Brain Dis 30:1063-71
Khan, Babar A; Lasiter, Sue; Boustani, Malaz A (2015) CE: critical care recovery center: an innovative collaborative care model for ICU survivors. Am J Nurs 115:24-31; quiz 34, 46
Khan, Babar A; Gutteridge, Daniel; Campbell, Noll L (2015) Update on Pharmacotherapy for Prevention and Treatment of Post-operative Delirium: A Systematic Evidence Review. Curr Anesthesiol Rep 5:57-64
Nazir, Arif; Khan, Babar; Counsell, Steven et al. (2015) Impact of an inpatient geriatric consultative service on outcomes for cognitively impaired patients. J Hosp Med 10:275-80
Khan, Babar A; Fadel, William F; Tricker, Jason L et al. (2014) Effectiveness of implementing a wake up and breathe program on sedation and delirium in the ICU. Crit Care Med 42:e791-5
Calvo-Ayala, Enrique; Khan, Babar A; Farber, Mark O et al. (2013) Interventions to improve the physical function of ICU survivors: a systematic review. Chest 144:1469-80
Calvo-Ayala, Enrique; Khan, Babar (2013) Delirium management in critically ill patients. J Symptoms Signs 2:23-32
Khan, Babar A; Farber, Mark O; Campbell, Noll et al. (2013) S100 calcium binding protein B as a biomarker of delirium duration in the intensive care unit - an exploratory analysis. Int J Gen Med 6:855-61
Nazir, Arif; LaMantia, Michael; Chodosh, Joshua et al. (2013) Interaction between cognitive impairment and discharge destination and its effect on rehospitalization. J Am Geriatr Soc 61:1958-63

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