Dr. Gloria Yeh's long-term career goal is to become an independent clinician investigator focusing on the critical evaluation, mechanistic understanding, and successful integration of evidence-based complementary and alternative medical (CAM) therapies for patients with cardiovascular disease and heart failure. Her immediate career objectives are: to enhance her methodological skills in clinical trial design and health services research through coursework, educational seminars, and the development of three rigorous, mentored studies; to understand the potential psychosocial and physiological mechanisms by which mind-body exercise can improve clinical outcome in cardiac patients; and to define the potential role of mind-body exercise and other CAM modalities in the current management of patients with cardiovascular disease. This proposal includes three projects with a particular focus on mind-body exercise in patients with chronic heart failure. The first will be a secondary database analysis describing the patterns and prevalence of CAM use in a large national sample of patients with cardiac disease and examining the factors associated with perceived beneficial use of tai chi, qigong, or yoga. The second and main project will be a pilot randomized controlled trial (n=20) evaluating study feasibility and safety of a 12-week tai chi/qigong program in older patients with diastolic heart failure. This study will provide important preliminary data regarding potential psychosocial effects (e.g., change in self-efficacy, mood, quality-of-life) and physiological mechanisms (e.g., change in exercise capacity, autonomic tone, neurohormone status) in preparation for a future R01application for a larger randomized clinical trial. The third project will assess current cardiac rehabilitation programs available to patients with cardiovascular disease and heart failure to begin to explore the incorporation of mind-body exercise into these rehabilitation programs and to understand the perceived successful psychosocial program components (e.g., factors that can enhance patient self-efficacy and program adherence). Completion of the proposed research and career development activities will enhance Dr. Yeh's ability to conduct patient-oriented research and allow her to achieve her career goal of becoming an independent clinical researcher investigating CAM therapies and its applications to patients with cardiac disease.
| Yeh, Gloria Y; Wood, Malissa J; Wayne, Peter M et al. (2013) Tai chi in patients with heart failure with preserved ejection fraction. Congest Heart Fail 19:77-84 |
| Yeh, Gloria Y; McCarthy, Ellen P; Wayne, Peter M et al. (2011) Tai chi exercise in patients with chronic heart failure: a randomized clinical trial. Arch Intern Med 171:750-7 |
| Yeh, Gloria Y; Roberts, David H; Wayne, Peter M et al. (2010) Tai chi exercise for patients with chronic obstructive pulmonary disease: a pilot study. Respir Care 55:1475-82 |
| Yeh, Gloria Y; Wang, Chenchen; Wayne, Peter M et al. (2009) Tai chi exercise for patients with cardiovascular conditions and risk factors: A SYSTEMATIC REVIEW. J Cardiopulm Rehabil Prev 29:152-60 |
| Birdee, Gurjeet S; Wayne, Peter M; Davis, Roger B et al. (2009) T'ai chi and qigong for health: patterns of use in the United States. J Altern Complement Med 15:969-73 |
| Yeh, Gloria Y; Mietus, Joseph E; Peng, Chung-Kang et al. (2008) Enhancement of sleep stability with Tai Chi exercise in chronic heart failure: preliminary findings using an ECG-based spectrogram method. Sleep Med 9:527-36 |
| Yeh, Gloria Y; Ryan, Mary Anne; Phillips, Russell S et al. (2008) Doctor training and practice of acupuncture: results of a survey. J Eval Clin Pract 14:439-45 |
| Yeh, Gloria Y; Wang, Chenchen; Wayne, Peter M et al. (2008) The effect of tai chi exercise on blood pressure: a systematic review. Prev Cardiol 11:82-9 |
| Buettner, Catherine; Yeh, Gloria Y; Phillips, Russell S et al. (2006) Systematic review of the effects of ginseng on cardiovascular risk factors. Ann Pharmacother 40:83-95 |
