Dr. Jun Mao, an Assistant Professor of Family Medicine and certified acupuncturist, is applying for a Mentored Patient-Oriented Research Career Development Award (K23) to become an independent translational researcher focusing on complementary and alternative medicine (CAM). The candidate seeks to conduct multidisciplinary research on the effects and mechanisms of acupuncture for symptom management in cancer. The substantial placebo effect observed in previous acupuncture trials presents a major limitation for studying acupuncture and interpreting experimental results. Therefore, the candidate proposes a comprehensive research and training program to investigate the placebo effect of acupuncture using hot flashes among breast cancer survivors as a clinical model. This K23 will provide the candidate with additional training in advanced research design, neuroimaging, and behavioral science to augment his initial research training in epidemiology. It will also provide mentored research experience through the conduct of a randomized controlled trial (RCT) to determine the magnitude of response to placebo acupuncture vs. placebo pill for hot flashes among breast cancer survivors. Furthermore, a feasibility study on functional brain imaging has been proposed among a subset of acupuncture trial participants to explore the use of serotonin transport binding as a potential biomarker to visualize acupuncture's effects for hot flashes. A group of multidisciplinary mentors has been assembled to support the candidate's career and research development, including Drs. John Farrar (acupuncture research methodology), Marjorie Bowman (leadership development and women's health), Andrew Newberg (neuroimaging), Caryn Lerman (behavioral science), Linda Jacobs (cancer survivorship), Deborah Bruner (symptom assessment), Sharon Xie (biostatistics) and Jay Amsterdam (biological psychiatry). The proposed research will provide an important methodological step leading to further investigation of the effects and mechanisms of acupuncture for hot flashes. Because hot flashes are a common symptom experienced by breast cancer survivors, and because existing conventional therapies are highly limited, this research and its follow-up investigation have the potential to benefit millions of women with a history of breast cancer. Furthermore, the mentored research experience and protected time provided by this K23 will allow Dr. Mao to develop into a leading translational scientist who can bridge neurobiology and clinical response of acupuncture for symptom management in cancer.

National Institute of Health (NIH)
National Center for Complementary & Alternative Medicine (NCCAM)
Mentored Patient-Oriented Research Career Development Award (K23)
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Special Emphasis Panel (ZAT1-LD (22))
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Huntley, Kristen V
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University of Pennsylvania
Family Medicine
Schools of Medicine
United States
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Mao, Jun J; Xie, Sharon X; Farrar, John T et al. (2014) A randomised trial of electro-acupuncture for arthralgia related to aromatase inhibitor use. Eur J Cancer 50:267-76
Bauml, Joshua; Basal, Coby; Mao, Jun J (2014) Treatment of post-mastectomy pain syndrome with acupuncture: a case report. Acupunct Med 32:183-5
Bauml, Joshua; Langer, Corey J; Evans, Tracey et al. (2014) Does perceived control predict Complementary and Alternative Medicine (CAM) use among patients with lung cancer? A cross-sectional survey. Support Care Cancer 22:2465-72
Shabason, Jacob E; Mao, Jun J; Frankel, Eitan S et al. (2014) Shared decision-making and patient control in radiation oncology: implications for patient satisfaction. Cancer 120:1863-70
Ho, Tiffany F; Rowland-Seymour, Anastasia; Frankel, Eitan S et al. (2014) Generational differences in complementary and alternative medicine (CAM) use in the context of chronic diseases and pain: baby boomers versus the silent generation. J Am Board Fam Med 27:465-73
Garland, Sheila N; Palmer, Christina; Donelson, Michelle et al. (2014) A nested case-controlled comparison of telomere length and psychological functioning in breast cancer survivors with and without insomnia symptoms. Rejuvenation Res 17:453-7
Mao, Jun J; Farrar, John T; Bruner, Deborah et al. (2014) Electroacupuncture for fatigue, sleep, and psychological distress in breast cancer patients with aromatase inhibitor-related arthralgia: a randomized trial. Cancer 120:3744-51
Frankel, Eitan; Garland, Sheila; Meghani, Salimah H et al. (2014) Patients' Perspectives on Integrating Acupuncture into the Radiation Oncology Setting. Eur J Integr Med 6:532-537
Brown, Justin C; Mao, Jun J; Stricker, Carrie et al. (2014) Aromatase inhibitor associated musculoskeletal symptoms are associated with reduced physical activity among breast cancer survivors. Breast J 20:22-8
Mao, Jun J; Chung, Annie; Benton, Adrian et al. (2013) Online discussion of drug side effects and discontinuation among breast cancer survivors. Pharmacoepidemiol Drug Saf 22:256-62

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