application) Anorexia Nervosa (AN) is a psychiatric illness that is characterized by extreme weight loss and severe body image distortions. The purpose of this Mentored Patient-Oriented Research Career Development Award (MPORCDA) is to develop and execute a program of research that will investigate the potential biological predispositions that contribute to the difficulty patients have in maintaining normal weight, with the long-term goal being to design treatment strategies to address the biological abnormalities. More specifically, it will test the hypotheses that 1) Weight-restored patients with anorexia nervosa have elevated resting energy expenditure (REE) compared to controls 2) Weight-restored patients with anorexia nervosa have a central distribution of body fat compared to controls 3) Weight-restored patients with anorexia nervosa who gain the most fat centrally will have the least improvement on psychological measures 4) Weight-restored patients with AN have leptin levels out of proportion to body fat mass. It will also investigate the relationship between REE and leptin with respect to return of menses. Under the strong mentorship of Dr. B. Timothy Walsh (for clinical research training and expertise in Anorexia Nervosa), Dr. Rudolph L. Leibel (for the metabolic aspects of body weight regulation and obesity), and Dr. Richard N. Pierson (for assessment and application body composition measurement), this MPORCDA will provide the principal investigator with the skills and further experience to integrate the advances of the fields of anorexia nervosa, obesity and weight regulation, and body composition. The long-term goal of this award is for the candidate to become an expert and independent researcher in the psychobiology of weight regulation and body composition assessment, with special application to anorexia nervosa.
| Schebendach, Janet; Mayer, Laurel E S; Devlin, Michael J et al. (2012) Dietary energy density and diet variety as risk factors for relapse in anorexia nervosa: a replication. Int J Eat Disord 45:79-84 |
| Schebendach, Janet E; Mayer, Laurel E; Devlin, Michael J et al. (2011) Food choice and diet variety in weight-restored patients with anorexia nervosa. J Am Diet Assoc 111:732-6 |
| Bodell, Lindsay P; Mayer, Laurel E S (2011) Percent body fat is a risk factor for relapse in anorexia nervosa: a replication study. Int J Eat Disord 44:118-23 |
| Mayer, Laurel E S; Klein, Diane A; Black, Elizabeth et al. (2009) Adipose tissue distribution after weight restoration and weight maintenance in women with anorexia nervosa. Am J Clin Nutr 90:1132-7 |
| Mayer, Laurel E S; Roberto, Christina A; Glasofer, Deborah R et al. (2007) Does percent body fat predict outcome in anorexia nervosa? Am J Psychiatry 164:970-2 |
| Heymsfield, Steven B; Gallagher, Dympna; Mayer, Laurel et al. (2007) Scaling of human body composition to stature: new insights into body mass index. Am J Clin Nutr 86:82-91 |
| Klein, Diane Alix; Mayer, Laurel E S; Schebendach, Janet Ellen et al. (2007) Physical activity and cortisol in anorexia nervosa. Psychoneuroendocrinology 32:539-47 |
| Dominguez, Jennifer; Goodman, Linnea; Sen Gupta, Surupa et al. (2007) Treatment of anorexia nervosa is associated with increases in bone mineral density, and recovery is a biphasic process involving both nutrition and return of menses. Am J Clin Nutr 86:92-9 |
| Mayer, Laurel; Walsh, B Timothy; Pierson Jr, Richard N et al. (2005) Body fat redistribution after weight gain in women with anorexia nervosa. Am J Clin Nutr 81:1286-91 |
| Kim, Jaehee; Heshka, Stanley; Gallagher, Dympna et al. (2004) Intermuscular adipose tissue-free skeletal muscle mass: estimation by dual-energy X-ray absorptiometry in adults. J Appl Physiol 97:655-60 |
