Dr. Peter P. Reese, a National Research Service Award Fellow in the Renal Division at the University of Pennsylvania School of Medicine, is applying for a K-23 Patient Oriented Research Career Development Award to acquire further experience and skills for an academic career as an independent investigator focused on transplantation. This proposal outlines a 5-year multi-disciplinary training program consisting of research, coursework, and mentoring by Dr. Harold I. Feldman, Director of the Clinical Epidemology Unit at Penn's Center for Clinical Epidemology and Biostatistics. Dr. Reese will pursue coursework in epidemiology, biostatistics, health policy and medical ethics which pertain directly to his proposed K-23 project, and which will prepare him to lead future independent research programs related to renal transplantation. The prevalence of end-stage renal disease (ESRD) in the United States (US) continues to climb, with devastating consequences for patients including an elevated risk of cardiovascular death and the burden of chronic dialysis. The growing ESRD population has intensified the demand for kidney transplantation, which has been shown to reduce mortality and improve quality of life compared to chronic dialysis. Given a limited supply of deceased donor kidneys, transplant professionals have increasingly focused attention on living kidney transplantation. Maximizing this vital resource for transplant candidates could substantially reduce the burdens of ESRD. Large and unexplained variation exists in the magnitude of living kidney transplantation across renal transplant centers. Comprehensive transplantation records from the United Network of Organ Sharing offer a valuable opportunity to elucidate the factors underlying this variation. Through the proposed project, Dr. Reese will measure magnitude of living kidney transplantation within and across transplant centers, and identify center attributes associated with variation in the magnitude of living kidney transplantation. Understanding how transplant centers optimize or limit their patients'opportunities to obtain a live donor kidney transplant represents a crucial advance in developing strategies to expand access to transplantation overall.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23DK078688-05
Application #
8110570
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Rankin, Tracy L
Project Start
2007-07-01
Project End
2012-12-30
Budget Start
2011-07-01
Budget End
2012-12-30
Support Year
5
Fiscal Year
2011
Total Cost
$131,667
Indirect Cost
Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Reese, P P; Bloom, R D; Feldman, H I et al. (2014) Mortality and cardiovascular disease among older live kidney donors. Am J Transplant 14:1853-61
Reese, Peter P; Hwang, Hojun; Potluri, Vishnu et al. (2014) Geographic determinants of access to pediatric deceased donor kidney transplantation. J Am Soc Nephrol 25:827-35
Ruebner, Rebecca L; Reese, Peter P; Abt, Peter L (2014) Donation after cardiac death liver transplantation is associated with increased risk of end-stage renal disease. Transpl Int 27:1263-71
Mgbako, O; Glazier, A; Blumberg, E et al. (2013) Allowing HIV-positive organ donation: ethical, legal and operational considerations. Am J Transplant 13:1636-42
Goldberg, David S; Halpern, Scott D; Reese, Peter P (2013) Deceased organ donation consent rates among racial and ethnic minorities and older potential donors. Crit Care Med 41:496-505
Butala, Neel M; Reese, Peter P; Doshi, Mona D et al. (2013) Is delayed graft function causally associated with long-term outcomes after kidney transplantation? Instrumental variable analysis. Transplantation 95:1008-14
Ruebner, Rebecca L; Reese, Peter P; Denburg, Michelle R et al. (2013) End-stage kidney disease after pediatric nonrenal solid organ transplantation. Pediatrics 132:e1319-26
Reese, Peter P; Cappola, Anne R; Shults, Justine et al. (2013) Physical performance and frailty in chronic kidney disease. Am J Nephrol 38:307-15
Friedewald, John J; Reese, Peter P (2012) The kidney-first initiative: what is the current status of preemptive transplantation? Adv Chronic Kidney Dis 19:252-6
Cassuto, James R; Levine, Matthew H; Reese, Peter P et al. (2012) The influence of induction therapy for kidney transplantation after a non-renal transplant. Clin J Am Soc Nephrol 7:158-66

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