Mandy Brown Belfort, MD MPH is a neonatologist at Children's Hospital Boston and Instructor of Pediatrics at Harvard Medical School. This application for a K23 mentored career development award combines structured mentorship and training with a detailed research plan. The overall goal of this proposal is to train Dr. Belfort for a career as an independent patient-oriented researcher focused on the long term outcomes of early-life growth and nutrition. In full term infants, rapid infant gain is associated with long-term risks, such as overweight and high blood pressure, but whether rapid weight gain is similarly harmful in preterm infants is unclear. Rapid weight gain may also be beneficial, for example to neurodevelopment in preterm infants;whether rapid weight gain benefits neurodevelopment in full term populations is poorly understood. A better understanding of the balance of risks and benefits associated with rapid infant weight gain in both full term and preterm populations would inform guidelines for optimal infant weight gain patterns in these populations. For this award, Dr. Belfort aims first to assess the adiposity-related risks and neurocognitive benefits at school age associated with infant weight gain in 2 large, established cohorts of full term and preterm infants. Dr. Belfort will then build a decision analytic model to estimate the optimal rate of weight gain for full term and preterm infants, balancing adiposity-related risks with neurocognitive benefits through adulthood. This research plan builds directly on Dr. Belfort's previous training in epidemiology and health services research and her clinical expertise in neonatology. Her findings will provide critical information regarding patterns of weight gain that optimize long term health in full term and preterm populations. Dr. Belfort's unique resources include a supportive, accomplished multi-disciplinary mentorship team;access to 2 large, established, longitudinal cohorts of full term and preterm children;and advanced coursework in epidemiology and decision analysis. The proposed award will enable Dr. Belfort to make a substantial scientific contribution and to develop her career as an independent investigator.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23DK083817-05
Application #
8325591
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Hyde, James F
Project Start
2008-09-15
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2014-08-31
Support Year
5
Fiscal Year
2012
Total Cost
$148,954
Indirect Cost
$11,034
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Belfort, Mandy B; Rifas-Shiman, Sheryl L; Kleinman, Ken P et al. (2016) Infant Breastfeeding Duration and Mid-Childhood Executive Function, Behavior, and Social-Emotional Development. J Dev Behav Pediatr 37:43-52
Belfort, Mandy B; Cohen, Robyn T; Rhein, Lawrence M et al. (2016) Preterm infant growth and asthma at age 8 years. Arch Dis Child Fetal Neonatal Ed 101:F230-4
Belfort, Mandy B; Kuban, Karl C K; O'Shea, T Michael et al. (2016) Weight Status in the First 2 Years of Life and Neurodevelopmental Impairment in Extremely Low Gestational Age Newborns. J Pediatr 168:30-5.e2
Perng, Wei; Rifas-Shiman, Sheryl L; Kramer, Michael S et al. (2016) Early Weight Gain, Linear Growth, and Mid-Childhood Blood Pressure: A Prospective Study in Project Viva. Hypertension 67:301-8
Oken, Emily; Baccarelli, Andrea A; Gold, Diane R et al. (2015) Cohort profile: project viva. Int J Epidemiol 44:37-48
Lakshmanan, Ashwini; Santo, Eilann; McCormick, Marie C et al. (2014) Parental preference and ability to participate in web-based developmental screening and surveillance: preliminary evidence for preterm infants after NICU discharge. Clin Pediatr (Phila) 53:1278-84
Gordon, Joshua H; Leung, Angela M; Hale, Andrea R et al. (2014) No difference in urinary iodine concentrations between Boston-area breastfed and formula-fed infants. Thyroid 24:1309-13
Belfort, Mandy B; Gillman, Matthew W; Buka, Stephen L et al. (2013) Preterm infant linear growth and adiposity gain: trade-offs for later weight status and intelligence quotient. J Pediatr 163:1564-1569.e2
Belfort, Mandy B; Rifas-Shiman, Sheryl L; Kleinman, Ken P et al. (2013) Infant feeding and childhood cognition at ages 3 and 7 years: Effects of breastfeeding duration and exclusivity. JAMA Pediatr 167:836-44
Belfort, Mandy B; Santo, Eilann; McCormick, Marie C (2013) Using parent questionnaires to assess neurodevelopment in former preterm infants: a validation study. Paediatr Perinat Epidemiol 27:199-207

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