It is well recognized that in the United States asthma morbidity and mortality are increased in urban poor minority populations where increased exposures to outdoor and indoor particulate occur.
The specific aim of this study to assess the interactions between expression of common polymorphisms related to airway inflammation and health effects associated with particulate exposures among children with asthma. The investigators hope to define the interaction between expression of these polymorphisms and biological and health effects associated with particulate in a cohort of urban-poor predominantly minority children with mild to severe asthma who attend the Kunsberg School on the campus of National Jewish Hospital. Forty-five children who are students at the Kunsberg School will be followed on a daily basis over 4 consecutive school years beginning October 2007. Urine leukotriene E4 levels will be collected from each child on 16 consecutive schooldays and exhaled nitric oxide will be sampled as a marker of airway inflammation. Hourly ambient fine particulate concentrations will be monitored and personal exposure monitoring of particulate will be performed. Children will be assessed for expression of the glutathione-s-transferase m-1 and the 5-lipoxygenase tandem repeat polymorphisms. As these children attend school daily, the Kunsberg School provides a unique population in which individual exposures and asthma severity indices can be measured daily while other potentially confounding triggers can be monitored concurrently. In this way the interaction between genetic variability and environmental exposures can be precisely measured in children with asthma.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23ES015510-04
Application #
7826578
Study Section
Special Emphasis Panel (ZES1-LKB-C (K1))
Program Officer
Shreffler, Carol K
Project Start
2007-06-01
Project End
2012-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
4
Fiscal Year
2010
Total Cost
$173,598
Indirect Cost
Name
National Jewish Health
Department
Type
DUNS #
076443019
City
Denver
State
CO
Country
United States
Zip Code
80206
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Rabinovitch, Nathan; Mauger, David T; Reisdorph, Nichole et al. (2014) Predictors of asthma control and lung function responsiveness to step 3 therapy in children with uncontrolled asthma. J Allergy Clin Immunol 133:350-6
Rabinovitch, Nathan (2012) Urinary leukotriene E4 as a biomarker of exposure, susceptibility and risk in asthma. Immunol Allergy Clin North Am 32:433-45
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Rabinovitch, Nathan; Reisdorph, Nichole; Silveira, Lori et al. (2011) Urinary leukotriene E? levels identify children with tobacco smoke exposure at risk for asthma exacerbation. J Allergy Clin Immunol 128:323-7
Rabinovitch, Nathan; Graber, Nora J; Chinchilli, Vernon M et al. (2010) Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma. J Allergy Clin Immunol 126:545-51.e1-4
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Rabinovitch, Nathan; Strand, Matthew; Stuhlman, Kate et al. (2008) Exposure to tobacco smoke increases leukotriene E4-related albuterol usage and response to montelukast. J Allergy Clin Immunol 121:1365-71
Rabinovitch, Nathan (2007) Urinary leukotriene E4. Immunol Allergy Clin North Am 27:651-64;vii