Traumatic brain injury (TBI) alters the lives of many civilians and those involved in armed conflicts. Sequalae of TBI include depression in up to 30% of cases. Appearance of depression after TBI impairs recovery and results in sub-optimal re-integration into society. Treatment of post TBI depression relies on oral medications, whose efficacy and side effect profile is sub-optimal. Exercise training is effective in spontaneous depression as a stand-alone treatment and in conjunction with oral medications, and this may represent an alternative treatment option in the TBI population. Further, the pathophysiology of depression after TBI has yet to be examined with the full scientific rigor required. This project proposes to use exercise training of moderate intensity as a treatment for depression after TBI, while measuring biological markers as a way to investigate efficacy and provide insight into the pathophysiology. This mentored career development award would allow further training and education of the candidate in exercise training, depression, sophisticated imaging techniques and the analysis of such data. The candidate's career goal is to be an expert in depression after TBI, thereby improving outcome through understanding the pathophysiology and seeking population specific treatments. UT Southwestern is one of the leading academic medical centers in the United States, with a proven record of scientific excellence. Home to four Nobel Laureates, it is also the home institution of world renowned experts in depression and traumatic brain injury. Its major teaching institution, Parkland Memorial Hospital, maintains a Level One trauma designation, caring for 3000 trauma patients annually. Exercise training will take place at the Institute for Exercise and Environmental Medicine.

Public Health Relevance

Depression after traumatic brain injury hinders recovery and re-integration into society. This project seeks to use moderate intensity exercise training as a treatment for depression after TBI, thereby avoiding medication side-effects and providing general health benefits. Additionally, this project includes targeted biological and imaging measures to improve the understanding of the disease mechanisms.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Mentored Patient-Oriented Research Career Development Award (K23)
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Pediatrics Subcommittee (CHHD)
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Michel, Mary E
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Virginia Commonwealth University
Physical Medicine & Rehab
Schools of Medicine
United States
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Hudak, Anne M; Peng, Lifang; Marquez de la Plata, Carlos et al. (2014) Cytotoxic and vasogenic cerebral oedema in traumatic brain injury: assessment with FLAIR and DWI imaging. Brain Inj 28:1602-9
Hudak, Anne M; Sandel, M Elizabeth; Goldberg, Gary et al. (2013) Dr. Frances A. Hellebrandt: pioneering physiologist, physiatrist, and physical medicine and rehabilitation program visionary. PM R 5:639-46