Major depressive disorder (MOD) is a common and serious psychiatric illness. It is among the leading causes of disability and is the psychiatric disorder most frequently associated with suicide. Yet the treatment of MOD with antidepressant medication remains largely a trial-and-error process and little empirical evidence exists to guide treatment when suicide prevention is a priority. The purpose of this patient-oriented K-award is to develop and execute a program of research that will investigate clinical, neuropsychological and genetic predictors of response to different types of antidepressant medications in a high-risk sample of persons with MOD and a history of suicide attempt. Changes in clinical and neuropsychological components of depression and the diathesis for suicide will be compared during treatment with a serotonergic versus a non- serotonergic antidepressant. We will also determine whether functional polymorphisms in genes related to depression or the diathesis for suicide predict therapeutic effects of these antidepressants on mood or components of the diathesis for suicide. The principal investigator will carry out this program of research career development under the strong mentorship of Dr. J. John Mann (for training in the clinical neurobiology of depression and suicide). Active consultation and additional mentorship will come from Dr. A. John Rush (for training in antidepressant clinical trial design and execution), Dr. Bruce G. Pollock (for training in antidepressant pharmacogenetics), Dr. Joseph D. Terwilliger (for training in genetic epidemiology), Dr. John Keilp (for training in use of neuropsychological tests) and from Dr. Eva Petkova (for training in statistical analytic methods). This patient-oriented career development award will provide the principal investigator with the further experience and skills necessary to integrate clinical and scientific expertise in the field of depression and suicide clinical trials research. The long-term goal of this award is for the candidate to become an expert and independent clinical researcher on the treatment of depression with a special focus on suicide prevention.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23MH076049-05
Application #
7762711
Study Section
Interventions Research Review Committee (ITV)
Program Officer
Hill, Lauren D
Project Start
2006-02-06
Project End
2012-01-31
Budget Start
2010-02-01
Budget End
2012-01-31
Support Year
5
Fiscal Year
2010
Total Cost
$176,861
Indirect Cost
Name
Columbia University (N.Y.)
Department
Psychiatry
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Gorlyn, Marianne; Keilp, John; Burke, Ainsley et al. (2015) Treatment-related improvement in neuropsychological functioning in suicidal depressed patients: paroxetine vs. bupropion. Psychiatry Res 225:407-12
Beier, Anne Mette; Lauritzen, Lotte; Galfalvy, Hanga C et al. (2014) Low plasma eicosapentaenoic acid levels are associated with elevated trait aggression and impulsivity in major depressive disorder with a history of comorbid substance use disorder. J Psychiatr Res 57:133-40
Molero, Patricio; Grunebaum, Michael F; Galfalvy, Hanga C et al. (2014) Past suicide attempts in depressed inpatients: clinical versus research assessment. Arch Suicide Res 18:50-7
Liu, Joanne J; Galfalvy, Hanga C; Cooper, Thomas B et al. (2013) Omega-3 polyunsaturated fatty acid (PUFA) status in major depressive disorder with comorbid anxiety disorders. J Clin Psychiatry 74:732-8
Grunebaum, Michael F; Keilp, John G; Ellis, Steven P et al. (2013) SSRI versus bupropion effects on symptom clusters in suicidal depression: post hoc analysis of a randomized clinical trial. J Clin Psychiatry 74:872-9
Grunebaum, Michael F; Ellis, Steven P; Duan, Naihua et al. (2012) Pilot randomized clinical trial of an SSRI vs bupropion: effects on suicidal behavior, ideation, and mood in major depression. Neuropsychopharmacology 37:697-706
Sublette, M Elizabeth; Galfalvy, Hanga C; Fuchs, Dietmar et al. (2011) Plasma kynurenine levels are elevated in suicide attempters with major depressive disorder. Brain Behav Immun 25:1272-8
Grunebaum, Michael F; Galfalvy, Hanga C; Mortenson, Lindsey Y et al. (2010) Attachment and social adjustment: relationships to suicide attempt and major depressive episode in a prospective study. J Affect Disord 123:123-30
Nakagawa, Atsuo; Grunebaum, Michael F; Oquendo, Maria A et al. (2009) Clinical correlates of planned, more lethal suicide attempts in major depressive disorder. J Affect Disord 112:237-42
Grunebaum, Michael F; Galfalvy, Hanga C; Huang, Yung-yu et al. (2009) Association of X-box binding protein 1 ( XBP1) genotype with morning cortisol and 1-year clinical course after a major depressive episode. Int J Neuropsychopharmacol 12:281-3

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