Anorexia Nervosa (AN) is a serious psychiatric illness characterized by a relentless but irrational concern about becoming fat, and extreme distortions in the perception of body shape and weight. The eating-related thoughts and behaviors of individuals with AN are repetitive, stereotyped, and extremely resistent to change, even after weight normalization. The persistence of these patterns of thought and behavior are likely related to the high relapse rate seen in this illness. The purpose of this Mentored Patient-Oriented Research Career Development Award (MPORCDA) is to develop and execute a program of research investigating neurocognitive processes in AN, focusing on implicit learning. The broad aim is to explore whether individuals with AN have a disturbance in implicit learning that may constitute a vulnerability to the development of AN and its persistence. The research supported by this award will examine the specific hypothesis that 1) patients with AN have a deficit in implicit learning and are particularly impaired at shifting responses when contingencies change;2) these disturbances persist, albeit to a lesser degree, even after short-term weight recovery;3) performance on implicit learning tasks correlates with clinical course;3) abnormalities in implicit learning are correlated with neural circuitry abnormalities, similar to those seen in OCD;4) improvement in cognitive deficits in weight restored patients is associated with improved clinical course. A fuller understanding of the basis of the remarkable persistence of the disordered thought and behavior characteristics of AN should provide a foundation for the development of more effective treatments. Under the strong mentorship of Dr. B. Timothy Walsh (for clinical research training and expertise in Anorexia Nervosa), Dr. Yaakov Stern (for training in cognitive neuroscience), and Dr. Bradley Peterson (for training in functional neuroimaging) this MPORCDA will provide the principal investigator with the skills and further research experience to apply advances in translational cognitive neuroscience to the study of AN. The long- term goal of this award is for the candidate to become an expert and independent researcher focusing on mechanisms underlying the development and persistence of eating disorders, with special application to anorexia nervosa.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23MH076195-04
Application #
7858137
Study Section
Adult Psychopathology and Disorders of Aging Study Section (APDA)
Program Officer
Chavez, Mark
Project Start
2007-09-03
Project End
2012-05-31
Budget Start
2010-06-01
Budget End
2011-05-31
Support Year
4
Fiscal Year
2010
Total Cost
$177,250
Indirect Cost
Name
Columbia University (N.Y.)
Department
Psychiatry
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Foerde, Karin; Steinglass, Joanna E (2017) Decreased feedback learning in anorexia nervosa persists after weight restoration. Int J Eat Disord 50:415-423
Schebendach, Janet E; Call, Christine C; Attia, Evelyn et al. (2017) The effect of acute weight restoration on dietary fat preference in hospitalized patients with anorexia nervosa. Int J Eat Disord 50:148-151
Cha, Jiook; Ide, Jaime S; Bowman, F Dubois et al. (2016) Abnormal reward circuitry in anorexia nervosa: A longitudinal, multimodal MRI study. Hum Brain Mapp 37:3835-3846
Biezonski, Dominik; Cha, Jiook; Steinglass, Joanna et al. (2016) Evidence for Thalamocortical Circuit Abnormalities and Associated Cognitive Dysfunctions in Underweight Individuals with Anorexia Nervosa. Neuropsychopharmacology 41:1560-8
Godier, Lauren R; de Wit, Sanne; Pinto, Anthony et al. (2016) An investigation of habit learning in Anorexia Nervosa. Psychiatry Res 244:214-22
Decker, Johannes Hugo; Figner, Bernd; Steinglass, Joanna E (2015) On Weight and Waiting: Delay Discounting in Anorexia Nervosa Pretreatment and Posttreatment. Biol Psychiatry 78:606-14
Foerde, Karin; Steinglass, Joanna E; Shohamy, Daphna et al. (2015) Neural mechanisms supporting maladaptive food choices in anorexia nervosa. Nat Neurosci 18:1571-3
Steinglass, Joanna; Foerde, Karin; Kostro, Katrina et al. (2015) Restrictive food intake as a choice--a paradigm for study. Int J Eat Disord 48:59-66
Steinglass, Joanna E; Kaplan, Simona C; Liu, Ying et al. (2014) The (lack of) effect of alprazolam on eating behavior in anorexia nervosa: a preliminary report. Int J Eat Disord 47:901-4
Pinto, Anthony; Steinglass, Joanna E; Greene, Ashley L et al. (2014) Capacity to delay reward differentiates obsessive-compulsive disorder and obsessive-compulsive personality disorder. Biol Psychiatry 75:653-9

Showing the most recent 10 out of 17 publications