The goal of this Mentored Research Career Award (K23) application is to provide training and innovative models for research on the biological, genetic and behavioral mechanisms underlying the intergenerational transmission of psychiatric risk from mother to infant. The training will provide (1) advanced education in clinical and biological research methodology, and (2) extensive, mentored research experience in assessment and interpretation of neurobiological and genetic data. The training components will include formal coursework in the University of Michigan Clinical Research Design and Statistical Analysis Program (CRDSA) under the Michigan CTSA, and extended laboratory experiences through the University of Michigan Genetics Laboratory and Trauma, Stress, and Anxiety Research Group's neurobiological and psycho-physiological laboratories. Models will be developed to study intergenerational transmission of risk, focusing on mothers with PTSD, infant's genetic risk factors, and their impact on infants'neurobiological stress regulation. Two-hundred mothers (100 PTSD-positive and 100 trauma-exposed PTSD-negative) and their 7-month old infants will be studied. Infants will be genotyped for the """"""""risk"""""""" allele polymorphisms on the serotonin transporter promoter gene, which has been robustly identified in the current literature as related to unique variation in capacity for distress regulation. Mother-infant dyads will be studied in several low-and high challenge interactions (Free Play, Teaching Task, and Still Face Paradigm) with measurement of behavioral and neurobiological stress responses (cortisol, heart rate variability). We hypothesize that (1) maternal PTSD will predict less optimal infant neurobiological stress regulation, and this link will be mediated by maternal behavior;(2) presence of genetic """"""""risk"""""""" in the infant will predict less optimal infant neurobiological stress regulation, and this relation will be moderated by maternal behavior. The combination of didactic training, mentored research experience and model development will provide the applicant with the knowledge, skills, and high quality preliminary data needed for the subsequent success as an independently funded clinical scientist, studying the complex, transactional, and longitudinal pathways of intergenerational risk transmission.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23MH080147-04
Application #
8096689
Study Section
Biobehavioral Mechanisms of Emotion, Stress and Health Study Section (MESH)
Program Officer
Garvey, Marjorie A
Project Start
2008-09-22
Project End
2013-02-28
Budget Start
2011-07-01
Budget End
2013-02-28
Support Year
4
Fiscal Year
2011
Total Cost
$178,663
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Psychiatry
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Rosenblum, Katherine L; Muzik, Maria; Morelen, Diana M et al. (2017) A community-based randomized controlled trial of Mom Power parenting intervention for mothers with interpersonal trauma histories and their young children. Arch Womens Ment Health 20:673-686
Muzik, Maria; Umarji, Rujuta; Sexton, Minden B et al. (2017) Family Social Support Modifies the Relationships Between Childhood Maltreatment Severity, Economic Adversity and Postpartum Depressive Symptoms. Matern Child Health J 21:1018-1025
Sexton, Minden B; Davis, Margaret T; Menke, Rena et al. (2017) Mother-child interactions at six months postpartum are not predicted by maternal histories of abuse and neglect or maltreatment type. Psychol Trauma 9:622-626
Rosenblum, Katherine; Lawler, Jamie; Alfafara, Emily et al. (2017) Improving Maternal Representations in High-Risk Mothers: A Randomized, Controlled Trial of the Mom Power Parenting Intervention. Child Psychiatry Hum Dev :
Muzik, Maria; Morelen, Diana; Hruschak, Jessica et al. (2017) Psychopathology and parenting: An examination of perceived and observed parenting in mothers with depression and PTSD. J Affect Disord 207:242-250
Fava, Nicole M; Simon, Valerie A; Smith, Erin et al. (2016) Perceptions of general and parenting-specific posttraumatic change among postpartum mothers with histories of childhood maltreatment. Child Abuse Negl 56:20-9
Muzik, Maria; McGinnis, Ellen W; Bocknek, Erika et al. (2016) PTSD SYMPTOMS ACROSS PREGNANCY AND EARLY POSTPARTUM AMONG WOMEN WITH LIFETIME PTSD DIAGNOSIS. Depress Anxiety 33:584-91
Muzik, Maria; Hamilton, Susan E (2016) Use of Antidepressants During Pregnancy?: What to Consider when Weighing Treatment with Antidepressants Against Untreated Depression. Matern Child Health J 20:2268-2279
McGinnis, Ellen W; Lopez-Duran, Nestor; Martinez-Torteya, Cecilia et al. (2016) Cortisol Awakening Response and Internalizing Symptoms Across Childhood: Exploring the Role of Age and Externalizing Symptoms. Int J Behav Dev 40:289-295
Morelen, Diana; Menke, Rena; Rosenblum, Katherine Lisa et al. (2016) Understanding Bidirectional Mother-Infant Affective Displays across Contexts: Effects of Maternal Maltreatment History and Postpartum Depression and PTSD Symptoms. Psychopathology 49:305-314

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