This Mentored Patient-Oriented Career Development Award (K23) application is designed to advance the candidate's long-term career goal of becoming an independent clinician scientist to improve psychosocial treatment of social anxiety disorder (SAD), a major public health problem. SAD symptoms include excessive negative social-evaluative beliefs and attentional bias for threat-relevant stimuli (e.g., "harsh" faces). Neuroimaging evidence suggests SAD involves dysfunction in prefrontal regions that interact with limbic regions engaged in threat processing. Cognitive behavioral therapy (CBT) is a widely used first-line treatment in SAD;however, many do not fully recover with CBT. The cognitive component of CBT requires higher-order functions (e.g., ability to reframe a feared situation to make it less fearful). Therapeutic success is associated with reduction/elimination of negative beliefs and attentional bias even though modification of implicit bias is not a target of intervention. This has important implications for better understanding neural mechanisms of CBT. Specifically, it is not clear if reductions in negative beliefs and attentional bias are due to overlapping or relatively distinct prefrontal regions. The proposed project includes a hands-on pre/post-CBT functional magnetic resonance imaging (fMRI) study to elucidate specific neural mechanisms in SAD recovery. The candidate will build on her strong CBT background for SAD and gain mentoring by experts in the fields of brain imaging of emotion and emotion-cognition interactions (Drs. Phan, Liberzon);cognitive affective neuroscience (Drs. Phan, Abelson, Liberzon);attentional and cognitive probes of SAD and translational clinical trials (Drs. Gross, Amir);and psychotherapy outcome research (Drs. Himle, Rauch). Participants will comprise 50 patients with generalized SAD and 25 matched healthy controls. An attentional task to ignore harsh faces and a reappraisal task to reframe harsh faces will be used to examine the effects of CBT on prefrontal regions implicated in implicit and explicit emotion regulation, respectively. Short-term training goals are: 1) advanced training in Neuroimaging (fMRI) Research Methodology and Statistics, 2) increased knowledge in Cognitive Affective Neuroscience, and 3) advanced training in Psychosocial Treatment Clinical Trials Methodology. IMPACT: Social anxiety disorder is highly prevalent and disabling;a better understanding of CBT brain mechanisms and of individual differences in treatment response will improve our understanding of CBT thereby optimizing current interventions and contribute to the advancement of new, more refined therapies to increase the probability of therapeutic success.

Public Health Relevance

Cognitive behavioral treatment (CBT) is a widely used first-line treatment for social anxiety disorder (SAD), a prevalent, debilitating disorder. Although many do not fully recover from SAD with CBT, the specific mechanisms by which CBT exerts its therapeutic effects are unknown. The primary goal of this research is to discover the effects of CBT on brain function, particularly in relation to specific emotion regulation strategies implicated in CBT-namely, increased attentional control over threat stimuli and higher-order cognitive regulation of emotions evoked by threat-relevant stimuli. A better understanding of the brain mechanisms of CBT and of individual differences in treatment response in patients with SAD will improve our understanding of CBT mechanisms thereby optimizing current therapies and contributing to the advancement of improved therapies to increase the probability of therapeutic success.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23MH093679-02
Application #
8469914
Study Section
Adult Psychopathology and Disorders of Aging Study Section (APDA)
Program Officer
Chavez, Mark
Project Start
2012-05-15
Project End
2017-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
2
Fiscal Year
2013
Total Cost
$189,575
Indirect Cost
$14,043
Name
University of Illinois at Chicago
Department
Psychiatry
Type
Schools of Medicine
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
Jacobs, R H; Barba, A; Gowins, J R et al. (2016) Decoupling of the amygdala to other salience network regions in adolescent-onset recurrent major depressive disorder. Psychol Med 46:1055-67
DiGangi, Julia A; Tadayyon, Armin; Fitzgerald, Daniel A et al. (2016) Reduced default mode network connectivity following combat trauma. Neurosci Lett 615:37-43
Burkhouse, Katie L; Kujawa, Autumn; Kennedy, Amy E et al. (2016) NEURAL REACTIVITY TO REWARD AS A PREDICTOR OF COGNITIVE BEHAVIORAL THERAPY RESPONSE IN ANXIETY AND DEPRESSION. Depress Anxiety 33:281-8
Klumpp, Heide; Fitzgerald, Daniel A; Piejko, Katherine et al. (2016) Prefrontal control and predictors of cognitive behavioral therapy response in social anxiety disorder. Soc Cogn Affect Neurosci 11:630-40
Gentili, Claudio; Cristea, Ioana Alina; Angstadt, Mike et al. (2016) Beyond emotions: A meta-analysis of neural response within face processing system in social anxiety. Exp Biol Med (Maywood) 241:225-37
Kujawa, Autumn; Wu, Minjie; Klumpp, Heide et al. (2016) Altered Development of Amygdala-Anterior Cingulate Cortex Connectivity in Anxious Youth and Young Adults. Biol Psychiatry Cogn Neurosci Neuroimaging 1:345-352
Wu, Minjie; Kujawa, Autumn; Lu, Lisa H et al. (2016) Age-related changes in amygdala-frontal connectivity during emotional face processing from childhood into young adulthood. Hum Brain Mapp 37:1684-95
Stange, Jonathan P; MacNamara, Annmarie; Barnas, Olga et al. (2016) Neural markers of attention to aversive pictures predict response to cognitive behavioral therapy in anxiety and depression. Biol Psychol :
Nelson, Brady D; Fitzgerald, Daniel A; Klumpp, Heide et al. (2015) Prefrontal engagement by cognitive reappraisal of negative faces. Behav Brain Res 279:218-25
Klumpp, Heide; Keutmann, Michael K; Fitzgerald, Daniel A et al. (2014) Resting state amygdala-prefrontal connectivity predicts symptom change after cognitive behavioral therapy in generalized social anxiety disorder. Biol Mood Anxiety Disord 4:14

Showing the most recent 10 out of 16 publications