This application for a Mentored Patient-Oriented Research Career Development Award proposes training and research designed to provide the candidate with a foundation to establish a successful career as an independent investigator with expertise in biobehavioral research on dimensions of neurocognition and negative affectivity that underlie eating disorder psychopathology. The training and research goals of this application are consistent with Strategy 1.4 of the NIMH Strategic Plan to develop new ways of classifying psychopathology for research based on behavioral and neurobiological dimensions. The candidate seeks advanced training in three areas: (1) dimensional and multi-method approaches to studying and classifying psychopathology, (2) neurocognition and associated tasks, and (3) neurobiology and the use of functional magnetic resonance imaging (fMRI) to study theoretically relevant neurocircuitry in eating disorders. Training will be guided by an interdisciplinary team of mentors and consultants and will involve formal (e.g., coursework, workshops) and informal (e.g., directed readings, mentoring meetings) activities across the funding period. The research plan proposes two studies to elucidate the role of neurocognitive and affective variables in eating disorder psychopathology. In the first study, dimensions of neurocognition (e.g., response inhibition, decision making) and negative affectivity (e.g., emotional reactivity, distress tolerance) will be examined in a broad sample of 80 women recruited from community and clinical settings who present with a range of clinically significant forms of eating disorder psychopathology. Participants will complete semi-structured interviews, self-report measures, and behavioral tasks to examine the extent to which the neurocognitive and affective dimensions are associated with cognitive and behavioral manifestations of eating disorder psychopathology. In the second study, a sample of 24 participants comprised of women with clinically significant eating disorder psychopathology involving binge eating (n=12) and non-eating disorder controls (n=12) will complete an fMRI protocol assessing resting-state activity and task-evoked activity associated with response inhibition and processing of negative affective stimuli. This study will provide data on neurocircuitry associated with inhibitory contro and affective functioning in eating disorder presentations characterized by binge eating. Importantly, these results may inform efforts to refine existing eating disorder treatments and develop new interventions targeting the biobehavioral variables under investigation. In sum, the advanced training goals and research proposed in this application will facilitate the candidate's success in becoming an independent investigator in patient-oriented research, with particular expertise in the field of eating disorders, as well as associated methodological and statistical approaches consistent with a novel program of research on dimensions of biobehavioral functioning underlying eating disorder psychopathology.

Public Health Relevance

Eating disorders are characterized by increased health care utilization, impaired role functioning, reduced quality of life, serious medical consequences, and elevated rates of suicide. The proposed project will help to clarify how dimensions of neurocognition and negative emotion relate to eating disorder symptoms, and may help to identify biobehavioral targets for the treatment of eating disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23MH101342-05
Application #
9266823
Study Section
Adult Psychopathology and Disorders of Aging Study Section (APDA)
Program Officer
Chavez, Mark
Project Start
2014-05-01
Project End
2019-04-30
Budget Start
2018-05-01
Budget End
2019-04-30
Support Year
5
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of California, San Diego
Department
Psychiatry
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Goldschmidt, Andrea B; Lavender, Jason M; Hipwell, Alison E et al. (2017) Emotion Regulation and Loss of Control Eating in Community-Based Adolescents. J Abnorm Child Psychol 45:183-191
Lavender, Jason M; Tull, Matthew T; DiLillo, David et al. (2017) Development and Validation of a State-Based Measure of Emotion Dysregulation. Assessment 24:197-209
Goldschmidt, Andrea B; Lavender, Jason M; Hipwell, Alison E et al. (2017) Examining Two Prevailing Models of Loss of Control Eating Among Community-Based Girls. Obesity (Silver Spring) :
Goldschmidt, Andrea B; O'Brien, Setareh; Lavender, Jason M et al. (2017) Executive functioning in a racially diverse sample of children who are overweight and at risk for eating disorders. Appetite :
Lavender, Jason M; Brown, Tiffany A; Murray, Stuart B (2017) Men, Muscles, and Eating Disorders: an Overview of Traditional and Muscularity-Oriented Disordered Eating. Curr Psychiatry Rep 19:32
Lavender, Jason M; Utzinger, Linsey M; Cao, Li et al. (2016) Reciprocal associations between negative affect, binge eating, and purging in the natural environment in women with bulimia nervosa. J Abnorm Psychol 125:381-6
Lavender, Jason M; Mason, Tyler B; Utzinger, Linsey M et al. (2016) Examining affect and perfectionism in relation to eating disorder symptoms among women with anorexia nervosa. Psychiatry Res 241:267-72
Lavender, Jason M; Utzinger, Linsey M; Crosby, Ross D et al. (2016) A naturalistic examination of the temporal patterns of affect and eating disorder behaviors in anorexia nervosa. Int J Eat Disord 49:77-83
Lavender, Jason M; Shaw, Jena A; Crosby, Ross D et al. (2015) Associations between weight suppression and dimensions of eating disorder psychopathology in a multisite sample. J Psychiatr Res 69:87-93
Lavender, Jason M; Wonderlich, Stephen A; Engel, Scott G et al. (2015) Dimensions of emotion dysregulation in anorexia nervosa and bulimia nervosa: A conceptual review of the empirical literature. Clin Psychol Rev 40:111-22

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