Cervical spondylotic myelopathy (CSM) is a common degenerative condition of the cervical spine that leads to pain and progressive spinal injury. Primary drivers of clinical injury in CSM include forward head posture (a biomechanical process) and spinal compression (a neuromechanical process). The current proposal seeks to define clinically-relevant radiographic biomarkers, using standard X-ray and Magnetization Transfer-MRI images, to investigate the role of head posture and spinal compression in CSM patients and age-matched controls. These biomarkers will then be directly correlated to anatomically-specific tests of clinical function, including pain, disability, strength, and coordination. The long-term goal is to develop standardized radiographic values and thresholds that can be used to identify appropriate surgical candidates and predict prognosis.

Public Health Relevance

This research proposal studies a debilitating spinal disease that is common in our aging population, known simply as ?cervical spinal compression?. This proposal seeks to develop precise radiographic markers as well as physical tests of injury in patients with this disease. Through this work we hope to improve our ability to a) identify patients who will benefit the most from surgery and b) better determine their trajectory of recovery after treatment.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23NS091430-03
Application #
9625800
Study Section
NST-2 Subcommittee (NST)
Program Officer
Babcock, Debra J
Project Start
2017-02-01
Project End
2022-01-31
Budget Start
2019-02-01
Budget End
2020-01-31
Support Year
3
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Neurosurgery
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Cloney, Michael; Smith, Andrew C; Coffey, Taylor et al. (2018) Fatty infiltration of the cervical multifidus musculature and their clinical correlates in spondylotic myelopathy. J Clin Neurosci 57:208-213
Hopkins, Benjamin S; Weber 2nd, Kenneth A; Cloney, Michael Brendan et al. (2018) Tract-Specific Volume Loss on 3T MRI in Patients With Cervical Spondylotic Myelopathy. Spine (Phila Pa 1976) 43:E1204-E1209