On a global basis, tropical infectious diseases take an enormous human toll, particularly affecting the poor and dispossessed. The candidate, an Associate Professor of Medicine with tenure, proposes a multifaceted mentoring and career development plan in patient-oriented research towards expanding research capacity in tropical infectious diseases and contributing to the improvement of global public health. This plan will build on the candidate's established strengths in malaria and leptospirosis field research in the developing country setting and provide opportunities for junior physician scientists to obtain formal training in tropical infectious disease research. The K24 award will protect the candidate's time to allow him to continue devoting more than 90% of his professional effort to research and mentoring. This program will include: one-on-one mentoring of junior physician scholars ('including medical students, MSTP students, internal medicine residents in a new global health track, infectious disease clinical fellows and junior clinical faculty members), the formal participation of the candidate in expanding UCSD's K30-funded clinical research training program to include training in international health and global infectious diseases;and professional development for the candidate to allow him to incorporate new skills into his research. The candidate proposes to obtain formal, mentored training in statistical genetics and systems biology to allow him to study genetic predisposition to infectious disease outcomes. Dr. Vinetz's ongoing patient-oriented research on malaria and leptospirosis will serve as research vehicles. His malaria research focuses on: 1) using molecular epidemiological approaches to delineate human reservoirs of malaria transmission, towards the design and deployment of novel approaches to malaria control;and 2) determining mechanisms of naturally acquired transmission-blocking immunity in the Peruvian Amazon population. His patient-oriented research in leptospirosis focuses on: 1) determining zoonotic reservoirs of leptospirosis transmission to humans;2) delineating anthropogenic influences on the environment that lead to human leptospirosis;and 3) determining host genetic determinants of the outcome of leptospiral infection. The K24 award will allow the candidate to continue and augment his successful patient-oriented research programs and provide the intellectual environment needed to increase the number of physician-scientists capable of carrying out cutting edge patient-oriented research in tropical infectious diseases and global health.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AI068903-05
Application #
7771792
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Rao, Malla R
Project Start
2006-03-01
Project End
2011-09-19
Budget Start
2010-03-01
Budget End
2011-09-19
Support Year
5
Fiscal Year
2010
Total Cost
$167,787
Indirect Cost
Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
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Rosas-Aguirre, Angel; Gamboa, Dionicia; Manrique, Paulo et al. (2016) Epidemiology of Plasmodium vivax Malaria in Peru. Am J Trop Med Hyg 95:133-144
Hupalo, Daniel N; Luo, Zunping; Melnikov, Alexandre et al. (2016) Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax. Nat Genet 48:953-8
Agampodi, Suneth B; Dahanayaka, Niroshan J; Nöckler, Karsten et al. (2016) Redefining Gold Standard Testing for Diagnosing Leptospirosis: Further Evidence from a Well-Characterized, Flood-Related Outbreak in Sri Lanka. Am J Trop Med Hyg 95:531-6
Wunder Jr, Elsio A; Figueira, Claudio P; Santos, Gisele R et al. (2016) Real-Time PCR Reveals Rapid Dissemination of Leptospira interrogans after Intraperitoneal and Conjunctival Inoculation of Hamsters. Infect Immun 84:2105-2115
Fouts, Derrick E; Matthias, Michael A; Adhikarla, Haritha et al. (2016) What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira. PLoS Negl Trop Dis 10:e0004403
RamachandraRao, Satish P; Matthias, Michael A; Kokoy-Mondragon, Chanthel et al. (2015) Proteomic analysis of urine exosomes reveals renal tubule response to leptospiral colonization in experimentally infected rats. PLoS Negl Trop Dis 9:e0003640
Torres, Katherine J; Castrillon, Carlos E; Moss, Eli L et al. (2015) Genome-level determination of Plasmodium falciparum blood-stage targets of malarial clinical immunity in the Peruvian Amazon. J Infect Dis 211:1342-51
Patra, Kailash P; Li, Fengwu; Carter, Darrick et al. (2015) Alga-produced malaria transmission-blocking vaccine candidate Pfs25 formulated with a human use-compatible potent adjuvant induces high-affinity antibodies that block Plasmodium falciparum infection of mosquitoes. Infect Immun 83:1799-808
Chuquiyauri, Raul; Molina, Douglas M; Moss, Eli L et al. (2015) Genome-Scale Protein Microarray Comparison of Human Antibody Responses in Plasmodium vivax Relapse and Reinfection. Am J Trop Med Hyg 93:801-9

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