The candidate, Dr. Carey Farquhar, proposes a mentoring program in global HIV/AIDS research for pre- and post-doctoral fellows and students pursuing a career in patient-oriented research at the University of Washington (UW) and in Kenya. Dr. Farquhar has a strong record in mentoring, having mentored more than 25 trainees since completing infectious disease fellowship in June 2002. She currently mentors 2 UW infectious disease fellows,1 UW post- doctoral fellow, 2 Kenyan post-doctoral fellows, and chairs 3 doctoral committees for students in the UW Department of Epidemiology, all of whom are actively involved in clinical or molecular epidemiology projects based in Nairobi. She has several ongoing studies with federal and non- federal funding that will provide opportunities for her trainees and through this award anticipates expanding her research agenda to include new studies focused on immune responses to common childhood infectious pathogens. The proposed research projects build on past collaborative work in mother-to-child HIV transmission, passive immunity and vaccination again common infant pathogens, particularly measles, a leading cause of infant morbidity and mortality in sub-Saharan Africa. The first project, """"""""Impact of Highly Active Antiretroviral Therapy during Pregnancy and Breastfeeding on Passive Transfer of Antibodies against Measles, Rotavirus, and Pneumococcus,"""""""" utilizes data from an existing randomized clinical trial and investigates non-HIV causes of morbidity and mortality in resource-limited settings. The second project, """"""""Sustainable Responses to Measles Vaccination among HIV-1-infected Children on HAART,"""""""" addresses an important gap in knowledge regarding responses to measles re-vaccination among Kenyan children on HAART. Dr. Farquhar proposes to use the K24 award to improve her research and mentoring skills, with special emphasis on building translational research capacity through work with the UW Institute for Translational Health Science and on training infectious disease fellows in Pediatrics and Medicine. The University of Washington is an ideal setting for her proposed mentoring program due to its rich and varied resources in global health and HIV/AIDS research and the increasing number of highly qualified applicants interested in conducting clinical research in a resource- limited setting. Without an understanding of protection against non-HIV pathogens, many children who avoid HIV-1 infection or are successfully treated with HAART will succumb to vaccine-preventable infections, such as measles. These two studies address problems of major public health importance and will allow Dr. Farquhar to continue mentoring US and Kenyan trainees as she broadens her research agenda.

Public Health Relevance

Without an understanding of protection against non-HIV pathogens, many children who avoid HIV-1 infection or are successfully treated with HAART will succumb to vaccine-preventable infections, such as measles. These two studies address problems of major public health importance and will allow Dr. Farquhar to continue mentoring US and Kenyan trainees as she broadens her research agenda.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AI087399-04
Application #
8501264
Study Section
Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
Program Officer
Miller, Judith A
Project Start
2010-07-01
Project End
2015-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2013
Total Cost
$128,287
Indirect Cost
$6,907
Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Bosire, Rose; Farquhar, Carey; Nduati, Ruth et al. (2017) Higher Transplacental Pathogen-Specific Antibody Transfer Among Pregnant Women Randomized to Triple Antiretroviral Treatment Versus Short Course Zidovudine. Pediatr Infect Dis J :
Njoroge, Anne; Guthrie, B L; Bosire, Rose et al. (2017) Low HDL-cholesterol among HIV-1 infected and HIV-1 uninfected individuals in Nairobi, Kenya. Lipids Health Dis 16:110
Cherutich, Peter; Golden, Matthew R; Wamuti, Beatrice et al. (2017) Assisted partner services for HIV in Kenya: a cluster randomised controlled trial. Lancet HIV 4:e74-e82
Krakowiak, Daisy; Kinuthia, John; Osoti, Alfred O et al. (2016) Home-Based HIV Testing Among Pregnant Couples Increases Partner Testing and Identification of Serodiscordant Partnerships. J Acquir Immune Defic Syndr 72 Suppl 2:S167-73
Aluisio, Adam R; Bosire, Rose; Bourke, Betz et al. (2016) Male Partner Participation in Antenatal Clinic Services is Associated With Improved HIV-Free Survival Among Infants in Nairobi, Kenya: A Prospective Cohort Study. J Acquir Immune Defic Syndr 73:169-76
Roxby, Alison C; Ben-Youssef, Leïla; Marx, Grace et al. (2016) Dual contraceptive method use in HIV-serodiscordant Kenyan couples. J Fam Plann Reprod Health Care 42:264-270
Cherutich, Peter; Golden, Matthew; Betz, Bourke et al. (2016) Surveillance of HIV assisted partner services using routine health information systems in Kenya. BMC Med Inform Decis Mak 16:97
Sharma, Monisha; Farquhar, Carey; Ying, Roger et al. (2016) Modeling the Cost-Effectiveness of Home-Based HIV Testing and Education (HOPE) for Pregnant Women and Their Male Partners in Nyanza Province, Kenya. J Acquir Immune Defic Syndr 72 Suppl 2:S174-80
Bosire, Rose; Betz, Bourke; Aluisio, Adam et al. (2016) High Rates of Exclusive Breastfeeding in Both Arms of a Peer Counseling Study Promoting EBF Among HIV-Infected Kenyan Women. Breastfeed Med 11:56-63
Guthrie, Brandon L; Introini, Andrea; Roxby, Alison C et al. (2015) Depot Medroxyprogesterone Acetate Use Is Associated With Elevated Innate Immune Effector Molecules in Cervicovaginal Secretions of HIV-1-Uninfected Women. J Acquir Immune Defic Syndr 69:1-10

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