The Specific Aims of this Midcareer Investigator Award application are to 1) successfully implement an ongoing randomized clinical trial in juvenile fibromyalgia 2) perform a prospective longitudinal study to determine long term prognosis of pediatric patients with juvenile fibromyalgia, and 3) use the candidate's ongoing and planned studies in the Pediatric Pain Research Program to train post-doctoral fellows and junior faculty in pediatric pain research. The Candidate's programmatic line of research focuses on physical and psychosocial functioning of children and adolescents with chronic pain, with an emphasis on juvenile fibromyalgia syndrome - a very poorly understood chronic pain condition for which there is no evidence- based treatment. The Research Plan includes two projects: a NIAMS funded multi-site randomized clinical trial (ROl) to test the efficacy of cognitive behavioral treatment for children and adolescents with juvenile fibromyalgia, and a longitudinal study of outcomes in juvenile fibromyalgia. The candidate's future plans are to use findings from current projects to develop the most effective treatments for juvenile fibromyalgia and other pediatric pain conditions. The Mentoring Plan is to train future clinical investigators in the field of clinical interventions and outcomes research in pediatric chronic pain. The candidate's plan consists of 1) individualized mentoring of postdoctoral fellows supported by two currently funded clinical trials (Treatment of Juvenile Fibromyalgia, and Chronic Pediatric Headaches), the proposed longitudinal study in juvenile fibromyalgia, and other ongoing clinical and translational research studies in pediatric pain 2) mentoring of fellows to develop their own independent research proposals and 3) participation of fellows in established didactic programs on manuscript and grant writing, clinical research methodology and responsible conduct of human research. Cincinnati Children's provides an ideal setting for this award because of the strong institutional support for patient-oriented research, presence of an award winning chronic pain program, support from the Divisional Data Core for methodological and data management issues, and a commitment of the institution to "change the outcomes" for pediatric patients.

Public Health Relevance

(See Instructions): This study meets the public health goal of better understanding and treating a poorly understood chronic pain condition of childhood (juvenile fibromyalgia) along with the goal of training the next generation of clinician-scientists in clinical and translational research in pediatric pain.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
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Serrate-Sztein, Susana
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Cincinnati Children's Hospital Medical Center
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Cunningham, Natoshia R; Lynch-Jordan, Anne; Barnett, Kimberly et al. (2014) Child pain catastrophizing mediates the relation between parent responses to pain and disability in youth with functional abdominal pain. J Pediatr Gastroenterol Nutr 59:732-8
Kashikar-Zuck, Susmita; Cunningham, Natoshia; Sil, Soumitri et al. (2014) Long-term outcomes of adolescents with juvenile-onset fibromyalgia in early adulthood. Pediatrics 133:e592-600
Lynch-Jordan, Anne M; Sil, Soumitri; Peugh, James et al. (2014) Differential changes in functional disability and pain intensity over the course of psychological treatment for children with chronic pain. Pain 155:1955-61
Lynch-Jordan, Anne M; Kashikar-Zuck, Susmita; Szabova, Alexandra et al. (2013) The interplay of parent and adolescent catastrophizing and its impact on adolescents' pain, functioning, and pain behavior. Clin J Pain 29:681-8
Kashikar-Zuck, Susmita; Sil, Soumitri; Lynch-Jordan, Anne M et al. (2013) Changes in pain coping, catastrophizing, and coping efficacy after cognitive-behavioral therapy in children and adolescents with juvenile fibromyalgia. J Pain 14:492-501
Joffe, Naomi E; Lynch-Jordan, Anne; Ting, Tracy V et al. (2013) Utility of the PedsQL rheumatology module as an outcome measure in juvenile fibromyalgia. Arthritis Care Res (Hoboken) 65:1820-7
Logan, Deirdre E; Claar, Robyn Lewis; Guite, Jessica W et al. (2013) Factor structure of the children's depression inventory in a multisite sample of children and adolescents with chronic pain. J Pain 14:689-98
Cunningham, Natoshia Raishevich; Kashikar-Zuck, Susmita (2013) Nonpharmacological treatment of pain in rheumatic diseases and other musculoskeletal pain conditions. Curr Rheumatol Rep 15:306
Verkamp, Emily K; Flowers, Stacy R; Lynch-Jordan, Anne M et al. (2013) A survey of conventional and complementary therapies used by youth with juvenile-onset fibromyalgia. Pain Manag Nurs 14:e244-50
Sil, Soumitri; Lynch-Jordan, Anne; Ting, Tracy V et al. (2013) Influence of family environment on long-term psychosocial functioning of adolescents with juvenile fibromyalgia. Arthritis Care Res (Hoboken) 65:903-9

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