The primary goals of this K24 competing renewal application are to enable Roger Weiss, M.D., to 1) continue to conduct and extend his patient-oriented research (POR) with drug dependent patients, particularly those with co-occurring disorders;and 2) provide intensive and high-quality mentorship to early-career investigators in POR. A K24 renewal will continue to give Dr. Weiss protected time for research and mentoring that would otherwise be spent on clinical and administrative duties. Dr. Weiss, Professor of Psychiatry at Harvard Medical School and Chief of the Division of Alcohol and Drug Abuse at McLean Hospital, Belmont, Massachusetts, has conducted POR since 1980, emphasizing studies that 1) integrate different treatment approaches, and 2) influence clinical practice. Since receiving a K24 award in September 2007, Dr. Weiss has accomplished the major goals of his original application. He has mentored 35 junior investigators, including 17 with K awards. He has authored 72 publications, including 34 publications with a mentee as first author. He successfully completed a randomized controlled trial of a """"""""community-friendly"""""""" version of Integrated Group Therapy that he developed for patients with bipolar disorder and substance dependence, and successfully led a multi-site study of prescription opioid dependence treatment in the NIDA Clinical Trials Network (CTN). Dr. Weiss'research plan for this renewal application includes continued work as a Node PI in the NIDA CTN, in which he is leading a long-term follow-up study of patients with prescription opioid dependence. He will also serve as Co-Investigator or consultant on several studies with mentees as PI. Further, he plans to submit proposals to 1) expand the scope of Integrated Group Therapy to include all mood disorders, and 2) study treatment approaches for pain clinic patients who misuse opioids. Dr. Weiss'mentoring plan includes training his mentees in 1) clinical aspects of drug abuse;2) designing and implementing drug abuse research studies;3) preparing scientific papers and presentations;4) writing successful grant applications;and 5) responsible conduct of research. He will accomplish this with a combination of individual and group meetings;collaborative mentoring;role modeling;and integrating mentoring with the Harvard Clinical and Translational Science Award (CTSA) Consortium. Dr. Weiss'career development plan involves learning more about treatment and clinical research with patients with severe pain and opioid dependence in a pain clinic;longitudinal data analytic strategies;and genetics. These activities will simultaneously enhance Dr. Weiss'research and his mentoring skills. The public health importance of this application is related to the need to develop new and effective treatments for drug dependent and dually diagnosed patients, and the need to train the next generation of investigators to develop the skills they require to effectively conduct POR with this patient population.

Public Health Relevance

The primary goals of this K24 competing renewal application are to enable Roger Weiss, M.D., to 1) continue to conduct and extend his patient-oriented research with drug dependent patients, particularly those with co-occurring disorders;and 2) provide intensive and high-quality mentorship to early-career investigators in patient-oriented research. The public health importance of this application is related to the need to develop new and effective treatments for drug dependent and dually diagnosed patients, and the need to train the next generation of investigators to develop the skills they require to effectively conduc research with this patient population.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
2K24DA022288-06
Application #
8382799
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Onken, Lisa
Project Start
2007-04-01
Project End
2017-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
6
Fiscal Year
2012
Total Cost
$175,294
Indirect Cost
$12,985
Name
Mclean Hospital
Department
Type
DUNS #
046514535
City
Belmont
State
MA
Country
United States
Zip Code
02478
McHugh, R Kathryn; Votaw, Victoria R; Fulciniti, Francesca et al. (2017) Perceived barriers to smoking cessation among adults with substance use disorders. J Subst Abuse Treat 74:48-53
Mackie, Susan E; McHugh, R Kathryn; McDermott, Katherine et al. (2017) Prevalence of restless legs syndrome during detoxification from alcohol and opioids. J Subst Abuse Treat 73:35-39
Hill, Kevin P; Palastro, Matthew D; Gruber, Staci A et al. (2017) Nabilone pharmacotherapy for cannabis dependence: A randomized, controlled pilot study. Am J Addict 26:795-801
Fitzmaurice, Garrett M; Lipsitz, Stuart R; Weiss, Roger D (2017) Statistical considerations in the choice of endpoint for drug use disorder trials. Drug Alcohol Depend 181:219-222
Medlock, Morgan M; Rosmarin, David H; Connery, Hilary S et al. (2017) Religious coping in patients with severe substance use disorders receiving acute inpatient detoxification. Am J Addict 26:744-750
Votaw, Victoria R; Wittenauer, Justine; Connery, Hilary S et al. (2017) Perceived risk of heroin use among nonmedical prescription opioid users. Addict Behav 65:218-223
Carroll, Kathleen M; Weiss, Roger D (2017) The Role of Behavioral Interventions in Buprenorphine Maintenance Treatment: A Review. Am J Psychiatry 174:738-747
McHugh, R Kathryn; Votaw, Victoria R; Bogunovic, Olivera et al. (2017) Anxiety sensitivity and nonmedical benzodiazepine use among adults with opioid use disorder. Addict Behav 65:283-288
Greenfield, Shelly F; Weiss, Roger D (2017) Addiction-25 Years Later. Harv Rev Psychiatry 25:97-100
Griffin, Margaret L; McDermott, Katherine A; McHugh, R Kathryn et al. (2016) Longitudinal association between pain severity and subsequent opioid use in prescription opioid dependent patients with chronic pain. Drug Alcohol Depend 163:216-21

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