We are submitting a proposal for a renewal of a K24 Mid-Career development Award to support the efforts of John N. van den Anker, M.D., Ph.D. Dr. van den Anker is a Board Certified Pediatrician who is also certified in Clinical Pharmacology;he is one of the only 30 pediatricians world-wide who has this dual certification and is one of the only two Neonatologists among them. Dr. van den Anker moved to Children's National Medical Center (CNMC) in 2002 to become Director of Pediatric Clinical Pharmacology, and he is currently Professor of Pediatrics, Pharmacology &Physiology at the George Washington University School of Medicine and Health Sciences (GWU). Significant institutional and departmental commitments, including financial support and an endowed Chair (Evan and Cindy Jones Professor of Pediatric Clinical Pharmacology) since 2005 have been provided to build a premier academic pediatric clinical research program. Dr. van den Anker is currently the P.I. of a number of external NIH grants in support of his pharmacological research. His expertise is in the area of developmental and neonatal pharmacology, primarily focusing on the effect of renal function on clinical pharmacokinetics of frequently used medicines in the neonate. His first K24 award (2004-2009) offered him the opportunity to gain skills in the general aspects of population pharmacokinetics and pharmacogenomics and to mentor 3-4 junior faculty members in pediatric pharmacology research. In this proposal, he plans to continue mentoring 3-4 junior faculty members who are conducting pharmacological studies in the areas of HIV/AIDS, psychiatry and anesthesiology. In addition, he will perform a research project that will focus on the development of a pharmacokinetic model for methadone dosing in neonates and young infants that will incorporate developmental changes (CYP2B6 activity and renal function) and pharmacogenetic information (CYP2B6 gene) relevant to methadone pharmacokinetics. The long-term goal of the proposed investigation is to improve the safe and effective use of methadone in neonates and young infants.

Public Health Relevance

The area of opiate exposed pregnant/postpartum women, and in utero or postnatally opiate exposed neonates urgently needs research to identify more effective medication treatment strategies. The research proposed in this project will result in evidence-based dosing guidelines for use of methadone in opiate-exposed neonates and young infants.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Human Development Research Subcommittee (NIDA)
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Biswas, Jamie
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Children's Research Institute
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Allegaert, Karel; Fanos, Vassilios; van den Anker, Johannes N et al. (2014) Perinatal pharmacology. Biomed Res Int 2014:101620
Ward, Robert M; Allegaert, Karel; de Groot, Ronald et al. (2014) Commentary: Continuous infusion of vancomycin in neonates: to use or not to use remains the question. Pediatr Infect Dis J 33:606-7
van den Anker, Johannes N (2014) How to optimize the evaluation and use of antibiotics in neonates. Early Hum Dev 90 Suppl 1:S10-2
De Cock, Roosmarijn F W; Allegaert, Karel; Brussee, Janneke M et al. (2014) Simultaneous pharmacokinetic modeling of gentamicin, tobramycin and vancomycin clearance from neonates to adults: towards a semi-physiological function for maturation in glomerular filtration. Pharm Res 31:2643-54
Samiee-Zafarghandy, Samira; Smith, P Brian; van den Anker, Johannes N (2014) Safety of sildenafil in infants*. Pediatr Crit Care Med 15:362-8
Allegaert, Karel; van de Velde, Marc; van den Anker, John (2014) Neonatal clinical pharmacology. Paediatr Anaesth 24:30-8
Allegaert, Karel; van den Anker, John N (2014) The addition of tramadol to a standard i.v. acetaminophen/morphine analgesia protocol in neonates: purposeful or just polypharmacy? Paediatr Anaesth 24:1189-90
Allegaert, Karel; van den Anker, John N (2014) Neonatal abstinence syndrome: on the evidence to add breastfeeding to any clinical pathway. Pediatr Crit Care Med 15:579-80
De Cock, Roosmarijn F W; Allegaert, Karel; Sherwin, Catherine M T et al. (2014) A neonatal amikacin covariate model can be used to predict ontogeny of other drugs eliminated through glomerular filtration in neonates. Pharm Res 31:754-67
Allegaert, Karel; van den Anker, John N (2014) Clinical pharmacology in neonates: small size, huge variability. Neonatology 105:344-9

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